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Mitochondrial DNA insertions into nuclear DNA affecting chromosome segregation: Insights for a novel mechanism of immunosenescence in mice
Publicat a:Mechanisms Of Ageing And Development. 207 111722- - 2022-01-01 207(), DOI: 10.1016/j.mad.2022.111722
Autors: González-Sánchez M; García-Martínez V; Bravo S; Kobayashi H; Martínez de Toda I; González-Bermúdez B; Plaza GR; De la Fuente M
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Mitochondrial DNA sequences were found inserted in the nuclear genome of mouse peritoneal T lymphocytes that increased progressively with aging. These insertions were preferentially located at the pericentromeric heterochromatin. In the same individuals, binucleated T-cells with micronuclei showed a significantly increased frequency associated with age. Most of them were positive for centromere sequences, reflecting the loss of chromatids or whole chromosomes. The proliferative capacity of T lymphocytes decreased with age as well as the glutathione reductase activity, whereas the oxidized glutathione and malondialdehyde concentrations exhibited a significant increase. These results may point to a common process that provides insights for a new approach to understanding immunosenescence. We propose a novel mechanism in which mitochondrial fragments, originated by the increased oxidative stress status during aging, accumulate inside the nuclear genome of T lymphocytes in a time-dependent way. The primary entrance of mitochondrial fragments at the pericentromeric regions may compromise chromosome segregation, causing genetic loss that leads to micronuclei formation, rendering aneuploid cells with reduced proliferation capacity, one of the hallmark of immunosenescence. Future experiments deciphering the mechanistic basis of this phenomenon are needed.
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Impacte bibliomètric. Anàlisi de la contribució i canal de difusió
El treball ha estat publicat a la revista Mechanisms Of Ageing And Development a causa de la seva progressió i el bon impacte que ha aconseguit en els últims anys, segons l'agència Scopus (SJR), s'ha convertit en una referència en el seu camp. A l'any de publicació del treball, 2022, es trobava a la posició , aconseguint així situar-se com a revista Q1 (Primer Cuartil), en la categoria Developmental Biology.
Independentment de l'impacte esperat determinat pel canal de difusió, és important destacar l'impacte real observat de la pròpia aportació.
Segons les diferents agències d'indexació, el nombre de citacions acumulades per aquesta publicació fins a la data 2025-07-13:
- Google Scholar: 1
- WoS: 1
- Scopus: 1