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Otero-Carrasco, BAutor o coautorUgarte Carro, EstherAutor o coautorPrieto-Santamaria, LAutor o coautorDiaz Uzquiano, MarinaAutor o coautorCaraca-Valente Hernandez, Juan PedroAutor o coautorRodriguez-Gonzalez, AAutor (correspondència)Identifying patterns to uncover the importance of biological pathways on known drug repurposing scenarios
Publicat a:Bmc Genomics. 25 (1): 43- - 2024-01-09 25(1), DOI: 10.1186/s12864-023-09913-1
Autors: Otero-Carrasco, B; Carro, EU; Prieto-Santamaría, L; Uzquiano, MD; Hernández, JPCV; Rodríguez-González, A
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Background Drug repurposing plays a significant role in providing effective treatments for certain diseases faster and more cost-effectively. Successful repurposing cases are mostly supported by a classical paradigm that stems from de novo drug development. This paradigm is based on the one-drug-one-target-one-disease idea. It consists of designing drugs specifically for a single disease and its drug's gene target. In this article, we investigated the use of biological pathways as potential elements to achieve effective drug repurposing.Methods Considering a total of 4214 successful cases of drug repurposing, we identified cases in which biological pathways serve as the underlying basis for successful repurposing, referred to as DREBIOP. Once the repurposing cases based on pathways were identified, we studied their inherent patterns by considering the different biological elements associated with this dataset, as well as the pathways involved in these cases. Furthermore, we obtained gene-disease association values to demonstrate the diminished significance of the drug's gene target in these repurposing cases. To achieve this, we compared the values obtained for the DREBIOP set with the overall association values found in DISNET, as well as with the drug's target gene (DREGE) based repurposing cases using the Mann-Whitney U Test.Results A collection of drug repurposing cases, known as DREBIOP, was identified as a result. DREBIOP cases exhibit distinct characteristics compared with DREGE cases. Notably, DREBIOP cases are associated with a higher number of biological pathways, with Vitamin D Metabolism and ACE inhibitors being the most prominent pathways. Additionally, it was observed that the association values of GDAs in DREBIOP cases were significantly lower than those in DREGE cases (p-value < 0.05).Conclusions Biological pathways assume a pivotal role in drug repurposing cases. This investigation successfully revealed patterns that distinguish drug repurposing instances associated with biological pathways. These identified patterns can be applied to any known repurposing case, enabling the detection of pathway-based repurposing scenarios or the classical paradigm.
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Impacte bibliomètric. Anàlisi de la contribució i canal de difusió
El treball ha estat publicat a la revista Bmc Genomics a causa de la seva progressió i el bon impacte que ha aconseguit en els últims anys, segons l'agència Scopus (SJR), s'ha convertit en una referència en el seu camp. A l'any de publicació del treball, 2024 encara no hi ha indicis calculats, però el 2023, es trobava a la posició , aconseguint així situar-se com a revista Q1 (Primer Cuartil), en la categoria Biotechnology.
Independentment de l'impacte esperat determinat pel canal de difusió, és important destacar l'impacte real observat de la pròpia aportació.
Segons les diferents agències d'indexació, el nombre de citacions acumulades per aquesta publicació fins a la data 2025-07-10:
- Google Scholar: 2
- WoS: 1
- Scopus: 4
Impacte i visibilitat social
Anàlisi del lideratge dels autors institucionals
Hi ha un lideratge significatiu, ja que alguns dels autors pertanyents a la institució apareixen com a primer o últim signant, es pot apreciar en el detall: Primer Autor (OTERO CARRASCO, BELEN) i Últim Autor (RODRIGUEZ GONZALEZ, ALEJANDRO).
l'autor responsable d'establir les tasques de correspondència ha estat RODRIGUEZ GONZALEZ, ALEJANDRO.