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Analysis of institutional authors

Aguirre De Carcer Garcia, IñigoAuthorParra-Nieto J.AuthorBaeza ACorresponding Author

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Inorganic Porous Nanoparticles for Drug Delivery in Antitumoral Therapy

Publicated to:Biotechnology Journal. 16 (2): e2000150- - 2021-01-01 16(2), DOI: 10.1002/biot.202000150

Authors: Parra-Nieto, Jorge; del Cid, Maria Amor Garcia; de Carcer, Inigo Aguirre; Baeza, Alejandro

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Abstract

© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The use of nanoparticles in oncology to deliver chemotherapeutic agents has received considerable attention in the last decades due to their tendency to be passively accumulated in solid tumors. Besides this remarkable property, the surface of these nanocarriers can be decorated with targeting moieties capable to recognize malignant cells which lead to selective nanoparticle uptake mainly in the diseased cells, without affecting the healthy ones. Among the different nanocarriers which have been developed with this purpose, inorganic porous nanomaterials constitute some of the most interesting due to their unique properties such as excellent cargo capacity, high biocompatibility and chemical, thermal and mechanical robustness, among others. Additionally, these materials can be engineered to present an exquisite control in the drug release behavior placing stimuli-responsive pore-blockers or sensitive hybrid coats on their surface. Herein, the recent advances developed in the use of porous inorganic nanomedicines will be described in order to provide an overview of their huge potential in the look out of an efficient and safe therapy against this complex disease. Porous inorganic nanoparticles have been designed to be accumulated in tumoral tissues; once there to recognize the target cell and finally, to release their payload in a controlled manner.

Keywords

antitumoral therapy, drug deliveryAntineoplastic agentsAntitumoral therapyAntitumoral therapy, drug deliveryCancer-therapyCo-deliveryDrug carriersDrug deliveryDrug delivery systemsEffective photodynamic therapyEfficientHumansMesoporous silica nanoparticlesMetal-organic frameworksMultidrug-resistanceNanocarriersNanomedicineNanomedicine, porous nanoparticles, targeted nanoparticlesNanoparticlesNeoplasmsPharmaceutical preparationsPhotothermal therapyPorosityPorous nanoparticlesSurface modificationTargeted nanoparticles

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Biotechnology Journal due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 13/79, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemical Research Methods.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 3.82. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 3.18 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 7.63 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-31, the following number of citations:

  • WoS: 48
  • Scopus: 56
  • OpenCitations: 55

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-31:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 69 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/87331/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 34
  • Downloads: 3

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (PARRA NIETO, JORGE) and Last Author (Baeza Garcia, Alejandro).

the author responsible for correspondence tasks has been Baeza Garcia, Alejandro.