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Analysis of institutional authors

Fernández-Jiménez N, Martinez-Garcia M, Varas J, Gil-Dones F, Santos Jl, Pradillo MAuthor

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January 1, 2024
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The scaffold nucleoporins SAR1 and SAR3 are essential for proper meiotic progression in Arabidopsis thaliana

Publicated to: Frontiers In Cell And Developmental Biology. 11 1285695- - 2023-12-04 11(), DOI: 10.3389/fcell.2023.1285695

Authors:

Fernández-Jiménez, N; Martinez-Garcia, M; Varas, J; Gil-Dones, F; Santos, JL; Pradillo, M
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Affiliations

GlaxoSmithKline plc, Spain - Author
GlaxoSmithKline Spain, Madrid, Spain - Author
Univ Complutense Madrid, Fac Biol Sci, Dept Genet Physiol & Microbiol, Madrid, Spain - Author
Univ Politecn Madrid, Sch Agr Food & Biosyst Engn, Dept Biotechnol Plant Biol, Madrid, Spain - Author
Universidad Complutense de Madrid - Author
Universidad Politécnica de Madrid - Author
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Abstract

Nuclear Pore Complexes (NPCs) are embedded in the nuclear envelope (NE), regulating macromolecule transport and physically interacting with chromatin. The NE undergoes dramatic breakdown and reformation during plant cell division. In addition, this structure has a specific meiotic function, anchoring and positioning telomeres to facilitate the pairing of homologous chromosomes. To elucidate a possible function of the structural components of the NPCs in meiosis, we have characterized several Arabidopsis lines with mutations in genes encoding nucleoporins belonging to the outer ring complex. Plants defective for either SUPPRESSOR OF AUXIN RESISTANCE1 (SAR1, also called NUP160) or SAR3 (NUP96) present condensation abnormalities and SPO11-dependent chromosome fragmentation in a fraction of meiocytes, which is increased in the double mutant sar1 sar3. We also observed these meiotic defects in mutants deficient in the outer ring complex protein HOS1, but not in mutants affected in other components of this complex. Furthermore, our findings may suggest defects in the structure of NPCs in sar1 and a potential link between the meiotic role of this nucleoporin and a component of the RUBylation pathway. These results provide the first insights in plants into the role of nucleoporins in meiotic chromosome behavior.
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Keywords

cellchromosome segregationenvelopegenehistone h3meiosismolecular architecturenuclear pore complexnup107-160 complexnup160nup96phd-finger proteinsar1sar3ArabidopsisMeiosisNuclear pore complexNuclear-pore complexNup160Nup96Sar1Sar3

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Frontiers In Cell And Developmental Biology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 5/39, thus managing to position itself as a Q1 (Primer Cuartil), in the category Developmental Biology.

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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-21:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 6.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 6 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (MARTINEZ GARCIA, MARINA) .

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