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Analysis of institutional authors

Perez-Ruiz, MCorresponding Author

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February 13, 2024
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Article

Mechanisms of ventilatory limitation to maximum exercise in children and adolescents with chronic airway diseases

Publicated to: PEDIATRIC PULMONOLOGY. 58 (11): 3293-3302 - 2023-11-01 58(11), DOI: 10.1002/ppul.26659

Authors:

Donadio, MVF; Barbosa, MA; Vendrusculo, FM; Ramirez, TI; Santana-Sosa, E; Sanz-Santiago, V; Perez-Ruiz, M
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Affiliations

Hosp Univ Infantil Nino Jesus Madrid, Dept Pulmonol, Madrid, Spain - Author
Pontificia Univ Catolica Rio Grande Do SulPUCRS, Infant Ctr, Lab Pediat Phys Act, Porto Alegre, Rio Grande Do S, Brazil - Author
Univ Europea Madrid, Fac Sport Sci, Dept Physiotherapy, Villaviciosa De Odon, Spain - Author
Univ Int Catalunya UIC, Fac Med & Hlth Sci, Dept Physiotherapy, Barcelona, Spain - Author
Univ Politecn Madrid UPM, Fac Phys Act & Sport Sci, Dept Hlth & Human Performance, INEF, C-Martin Fierro 7, Ciudad Univ, Madrid 28040, Spain - Author
Univ Politecn Madrid UPM, Fac Phys Act & Sport Sci, Dept Hlth & Human Performance, INEF, Madrid, Spain - Author
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Abstract

IntroductionExercise intolerance is common in chronic airway diseases (CAD), but its mechanisms are still poorly understood. The aim of this study was to evaluate exercise capacity and its association with lung function, ventilatory limitation, and ventilatory efficiency in children and adolescents with cystic fibrosis (CF) and asthma when compared to healthy controls.MethodsCross-sectional study including patients with mild-to-moderate asthma, CF and healthy children and adolescents. Anthropometric data, lung function (spirometry) and exercise capacity (cardiopulmonary exercise testing) were evaluated. Primary outcomes were peak oxygen consumption (VO2peak), forced expiratory volume in 1 s (FEV1), breathing reserve (BR), ventilatory equivalent for oxygen consumption (VE/VO2) and for carbon dioxide production (VE/VCO2), both at the ventilatory threshold (VT1) and peak exercise.ResultsMean age of 147 patients included was 11.8 & PLUSMN; 3.0 years. There were differences between asthmatics and CF children when compared to their healthy peers for anthropometric and lung function measurements. Asthmatics showed lower VO2peak when compared to both healthy and CF subjects, although no differences were found between healthy and CF patients. A lower BR was found when CF patients were compared to both healthy and asthmatic. Both CF and asthmatic patients presented higher values for VE/VO2 and VE/VCO2 at VT1 when compared to healthy individuals. For both VE/VO2 and VE/VCO2 at peak exercise CF patients presented higher values when compared to their healthy peers.ConclusionPatients with CF achieved good exercise capacity despite low ventilatory efficiency, low BR, and reduced lung function. However, asthmatics reported reduced cardiorespiratory capacity and normal ventilatory efficiency at peak exercise. These results demonstrate differences in the mechanisms of ventilatory limitation to maximum exercise testing in children and adolescents with CAD.
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Keywords

AdolescentAdultAged, 80 and overAnthropometryArticleAsthmaBody heightBody massBody weightBreathing reserveCapacityCarbon dioxide productionCardiopulmonary exercise testChildControlled studyCross-sectional studiesCross-sectional studyCystic fibrosisDisease severityEquivalent for oxygen consumptionExerciseExercise testExercise toleranceFemaleFitnessForced expiratory flowForced expiratory volumeForced vital capacityHealthyHumanHumansLung functionMajor clinical studyMaleMortalityOxygen consumptionPeak oxygen uptakePerformancePredictionPulmonary disease, chronic obstructiveRespiratory tract parametersRiskSpirometryVentilatory efficiencyVentilatory equivalent for carbon dioxide productionVentilatory equivalent for oxygen consumptionVentilatory limitationVentilatory threshold

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal PEDIATRIC PULMONOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 38/186, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pediatrics.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.02. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 1.33 (source consulted: FECYT Mar 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-27, the following number of citations:

  • WoS: 5
  • Scopus: 4
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-27:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 16.

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/87372/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 146
  • Downloads: 60
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Brazil.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (PEREZ RUIZ, MARGARITA).

the author responsible for correspondence tasks has been PEREZ RUIZ, MARGARITA.

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Project objectives

El estudio persigue los siguientes objetivos: analizar la capacidad de ejercicio en niños y adolescentes con fibrosis quística (FQ) y asma en comparación con controles sanos; evaluar la asociación entre la capacidad de ejercicio y la función pulmonar mediante espirometría; determinar los mecanismos de limitación ventilatoria, incluyendo reserva respiratoria (BR) y equivalentes ventilatorios para oxígeno (VE/VO2) y dióxido de carbono (VE/VCO2) en umbral ventilatorio y ejercicio máximo; caracterizar las diferencias en eficiencia ventilatoria y capacidad cardiorrespiratoria entre pacientes con FQ y asma; y comparar las variables antropométricas y funcionales entre los grupos estudiados para comprender mejor la intolerancia al ejercicio en enfermedades crónicas de las vías aéreas.
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Most relevant results

El estudio evaluó la capacidad de ejercicio y los mecanismos de limitación ventilatoria en niños y adolescentes con fibrosis quística (FQ), asma y controles sanos. Se observaron diferencias antropométricas y en la función pulmonar entre los grupos. Los pacientes asmáticos presentaron un VO2peak inferior respecto a sanos y FQ, sin diferencias entre estos últimos. Los pacientes con FQ mostraron una reserva respiratoria (BR) menor que los asmáticos y sanos. Tanto FQ como asmáticos exhibieron valores elevados de VE/VO2 y VE/VCO2 en el umbral ventilatorio (VT1) comparados con controles. Además, en ejercicio máximo, los pacientes con FQ mantuvieron mayores valores de VE/VO2 y VE/VCO2 frente a los sanos, evidenciando diferentes mecanismos de limitación ventilatoria según la enfermedad.
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Awards linked to the item

Familia Alonso Fundacion; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
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