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Analysis of institutional authors

Toribio, RAuthor

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April 11, 2024
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Translational Control of Alphavirus-Host Interactions: Implications in Viral Evolution, Tropism and Antiviral Response

Publicated to: Viruses-Basel. 16 (2): 205- - 2024-02-01 16(2), DOI: 10.3390/v16020205

Authors:

Ventoso, I; Berlanga, JJ; Toribio, R; Díaz-López, I
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Affiliations

MRC Lab Mol Biol - Author
Univ Autonoma Madrid UAM, Dept Biol Mol - Author
Univ Politecn Madrid, Ctr Biotecnol & Genom Plantas, Inst Nacl Invest & Tecnol Agr & Alimentaria UPM IN - Author
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Abstract

Alphaviruses can replicate in arthropods and in many vertebrate species including humankind, but only in vertebrate cells do infections with these viruses result in a strong inhibition of host translation and transcription. Translation shutoff by alphaviruses is a multifactorial process that involves both host- and virus-induced mechanisms, and some of them are not completely understood. Alphavirus genomes contain cis-acting elements (RNA structures and dinucleotide composition) and encode protein activities that promote the translational and transcriptional resistance to type I IFN-induced antiviral effectors. Among them, IFIT1, ZAP and PKR have played a relevant role in alphavirus evolution, since they have promoted the emergence of multiple viral evasion mechanisms at the translational level. In this review, we will discuss how the adaptations of alphaviruses to vertebrate hosts likely involved the acquisition of new features in viral mRNAs and proteins to overcome the effect of type I IFN.
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Keywords

AlphavirusAlphavirusesAnimalsAntiviral activityAntiviral agentsAntiviral responseAntivirus agentArthropodBinding affinityCapsid proteinCell lineCellular messenger-rnaChikungunya virusCis acting elementEif2 alpha phosphorylationEif2α phosphorylationEquine encephalitis-virusEvolutionGene expressionGenetic analysisGenome-wide association studyGeographic distributionHost interactionHost rangeHumanInitiation factor 2alphaInterferonInterferon type iKinase pkrMessenger rnaMicrornaMutational analysisNonhumanNonstructural protein nsp2Old-worldOpen reading framePlasmodium falciparumPolyadenylationProtein phosphorylationReplicationReviewRna binding proteinRna directed rna polymeraseRna polymeraseRna polymerase iiRna structureSemliki-forest-virusSindbis-virusTranslation initiationTranslation regulationTropismUbiquitin protein ligase e3VertebratesViral evolutionVirus infectionVirus replicationVirus rnaZoonotic transmission

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Viruses-Basel due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Infectious Diseases.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-26:

  • WoS: 8
  • Scopus: 8
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-26:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 19.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 19 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/90759/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 84
  • Downloads: 91
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United Kingdom.

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