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Analysis of institutional authors

González-García, MpAuthorSaez, AAuthorLanza, MncAuthorBustillo-Avendano, EAuthorPacios, LfAuthorMoreno-Risueno, MaAuthorDel Pozo, JcCorresponding Author

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April 11, 2024
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Synthetically derived BiAux modulates auxin co-receptor activity to stimulate lateral root formation

Publicated to: PLANT PHYSIOLOGY. 195 (2): 1694-1711 - 2024-05-31 195(2), DOI: 10.1093/plphys/kiae090

Authors:

Gonzalez-Garcia, Mary Paz; Saez, Angela; Lanza, Monica; Hoyos, Pilar; Bustillo-Avendano, Estefano; Pacios, Luis F; Gradillas, Ana; Moreno-Risueno, Miguel A; Hernaiz, Maria Jose; del Pozo, Juan C
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Affiliations

CEU Univ, Univ San Pablo CEU, Fac Farm, Ctr Metabol & Bioanal CEMBIO,CEU - Author
Univ Complutense Madrid, Fac Farm, Dept Quim Ciencias Farmaceut, Plaza Ramon y Cajal S-N - Author
Univ Francisco de Vitoria, Fac Ciencias Expt, Edificio E - Author
Univ Politecn Madrid UPM, Ctr Biotecnol & Genom Plantas UPM INIA CSIC, Inst Nacl Invest & Tecnol Agr & Alimentaria CSIC I, Campus Montegancedo - Author
Univ Politecn Madrid UPM, Escuela Tecn Super Ingn Agron Alimentaria & Biosis, Dept Biotecnol Biol Vegetal - Author
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Abstract

The root system plays an essential role in plant growth and adaptation to the surrounding environment. The root clock periodically specifies lateral root prebranch sites (PBS), where a group of pericycle founder cells (FC) is primed to become lateral root founder cells and eventually give rise to lateral root primordia or lateral roots (LRs). This clock-driven organ formation process is tightly controlled by modulation of auxin content and signaling. Auxin perception entails the physical interaction of TRANSPORT INHIBITOR RESPONSE 1 (TIR1) or AUXIN SIGNALING F-BOX (AFBs) proteins with AUXIN/INDOLE-3-ACETIC ACID (Aux/IAA) repressors to form a co-receptor system. Despite the apparent simplicity, the understanding of how specific auxin co-receptors are assembled remains unclear. We identified the compound bis-methyl auxin conjugated with N-glucoside, or BiAux, in Arabidopsis (Arabidopsis thaliana) that specifically induces the formation of PBS and the emergence of LR, with a slight effect on root elongation. Docking analyses indicated that BiAux binds to F-box proteins, and we showed that BiAux function depends on TIR1 and AFB2 F-box proteins and AUXIN RESPONSE FACTOR 7 activity, which is involved in FC specification and LR formation. Finally, using a yeast (Saccharomyces cerevisiae) heterologous expression system, we showed that BiAux favors the assemblage of specific co-receptors subunits involved in LR formation and enhances AUXIN/INDOLE-3-ACETIC ACID 28 protein degradation. These results indicate that BiAux acts as an allosteric modulator of specific auxin co-receptors. Therefore, BiAux exerts a fine-tune regulation of auxin signaling aimed to the specific formation of LR among the many development processes regulated by auxin. A synthetic version of a bis-methyl auxin conjugated with N-glucoside, or BiAux, specifically regulates the activity of auxin co-receptors involved in lateral root formation.
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Keywords

ArabidopsisArabidopsis proteinsArabidopsis-thalianaCell-cycle progressionDegradationF-boxF-box proteinsFamilyGeneGene expression regulation, plantGrowthIndoleacetic acidsMechanismOf-function mutationPerceptionPlant growth regulatorsPlant rootsReceptors, cell surfaceSignal transductionTir1 protein, arabidopsis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal PLANT PHYSIOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 17/273, thus managing to position itself as a Q1 (Primer Cuartil), in the category Plant Sciences. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-25:

  • WoS: 8
  • Scopus: 6
  • Europe PMC: 4
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-25:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 8.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 6 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 24.
  • The number of mentions on the social network Facebook: 2 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 26 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/93918/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 31
  • Downloads: 11
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (GONZALEZ GARCIA, MARIA DE LA PAZ) and Last Author (DEL POZO BENITO, JUAN CARLOS).

the author responsible for correspondence tasks has been DEL POZO BENITO, JUAN CARLOS.

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