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Grant support

This investigation was supported by the European Union's Horizon 2020 research and innovation program under the European Training Network BioImplant (Development of improved bioresorbable materials for orthopedic and vascular implant applications), Marie Sk & lstrok;odowska-Curie grant agreement No 813869. Additional support from the Spanish Research Agency through the grant PID2021-124389OB-C21 is also gratefully acknowledged.

Analysis of institutional authors

Gonzalez CAuthorGonzalez, CarlosAuthorLlorca, JavierCorresponding Author

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July 2, 2024
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Cytocompatibility, cell-material interaction, and osteogenic differentiation of MC3T3-E1 pre-osteoblasts in contact with engineered Mg/PLA composites

Publicated to:Journal Of Biomedical Materials Research Part a. 112 (12): 2136-2148 - 2024-06-20 112(12), DOI: 10.1002/jbm.a.37767

Authors: Ali W; Ordoño J; Kopp A; González C; Echeverry-Rendón M; LLorca J

Affiliations

IMDEA Mat, C Eric Kandel 2, Getafe 28906, Madrid, Spain - Author
Meotec GmbH, Aachen, Germany - Author
Univ Carlos III Madrid, Dept Mat Sci & Engn, Leganes, Madrid, Spain - Author
Univ Politecn Madrid, Dept Mat Sci, Madrid, Spain - Author

Abstract

Bioabsorbable Mg wire-reinforced poly-lactic acid (PLA) matrix composites are potential candidate for load-bearing orthopedic implants offering tailorable mechanical and degradation properties by stacking sequence, volume fraction and surface modification of Mg wires. In this study, we investigated the cytocompatibility, cell-material interaction, and bone differentiation behavior of MC3T3-E1 pre-osteoblast cells for medical-grade PLA, Mg/PLA, and PEO-Mg/PLA (having PEO surface modification on Mg wires) composites. MTT and live/dead assay showed excellent biocompatibility of both composites while cell-material interaction analysis revealed that cells were able to adhere and proliferate on the surface of composites. Cells on the longitudinal surface of composites showed a high and uniform cell density while those on transversal surfaces initially avoided Mg regions but later migrated back after the formation of the passivation layer. Bone differentiation tests showed that cells in extracts of PLA and composites were able to initiate the differentiation process as osteogenesis-related gene expressions, alkaline phosphatase protein quantity, and calcium mineralization increased after 7 and 14 days of culture. Interestingly, the bone differentiation response of PEO-Mg/PLA composite was found to be similar to medical-grade PLA, proving its superiority over Mg/PLA composite.

Keywords

Bioabsorbable compositesBiocompatibilityDegradationIn-vitroMagnesiumOsteosynthesis implantsPlaPlasma-electrolytic oxidationPlasma‐electrolytic oxidationSofSurface modificatioSurface modificationVivo

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Biomedical Materials Research Part a due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Metals and Alloys.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-15:

  • Scopus: 3

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-15:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 12 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Germany.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (LLORCA MARTINEZ, FCO. JAVIER).

the author responsible for correspondence tasks has been LLORCA MARTINEZ, FCO. JAVIER.