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Analysis of institutional authors

Liu, Yu-YaoAuthorLlorca, JavierCorresponding Author

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October 15, 2024
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Collagen-based 3D printed poly (glycerol sebacate) composite scaffold with biomimicking mechanical properties for enhanced cartilage defect repair

Publicated to: International Journal Of Biological Macromolecules. 280 135827- - 2024-11-01 280(), DOI: 10.1016/j.ijbiomac.2024.135827

Authors:

Liu, Yu-Yao; Intini, Claudio; Dobricic, Marko; O'Brien, Fergal J; O'Brien, Fergal J; Llorca, Javier; Echeverry-Rendon, Monica
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Affiliations

IMDEA Mat Inst, Madrid 28906, Spain - Author
RCSI, Adv Mat & Bioengn Res AMBER Ctr, Dublin, Ireland - Author
Royal Coll Surg Ireland RCSI, Dept Anat & Regenerat Med, Tissue Engn Res Grp, Dublin, Ireland - Author
TCD, Dublin, Ireland - Author
Trinity Coll Dublin TCD, Trinity Ctr Biomed Engn, Dublin 2, Ireland - Author
Univ Politecn Madrid, Polytech Univ Madrid, Dept Mat Sci, Madrid 28040, Spain - Author
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Abstract

Cartilage defect repair with optimal efficiency remains a significant challenge due to the limited self-repair capability of native tissues. The development of bioactive scaffolds with biomimicking mechanical properties and degradation rates matched with cartilage regeneration while simultaneously driving chondrogenesis, plays a crucial role in enhancing cartilage defect repair. To this end, a novel composite scaffold with hierarchical porosity was manufactured by incorporating a pro-chondrogenic collagen type I/II-hyaluronic acid (CI/II-HyA) matrix to a 3D-printed poly(glycerol sebacate) (PGS) framework. Based on the mechanical enforcement of PGS framework, the composite scaffold exhibited a compressive modulus of 167.0 kPa, similar to that of native cartilage, as well as excellent fatigue resistance, similar to that of native joint tissue. In vitro degradation tests demonstrated that the composite scaffold maintained structural, mass, and mechanical stability during the initial cartilage regeneration period of 4 weeks, while degraded linearly over time. In vitro biological tests with rat- derived mesenchymal stem cell (MSC) revealed that, the composite scaffold displayed increased cell loading efficiency and improved overall cell viability due to the incorporation of CI/II-HyA matrix. Additionally, it also sustained an effective and high-quality MSC chondrogenesis and abundant de-novo cartilage-like matrix deposition up to day 28. Overall, the biomimetic composite scaffold with sufficient mechanical support, matched degradation rate with cartilage regeneration, and effective chondrogenesis stimulation shows great potential to be an ideal candidate for enhancing cartilage defect repair.
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Keywords

3-d printing3d-printingAnimalAnimalsArticular cartilageArticular-cartilageBiocompatible materialsBiofilmBiomaterialBiomechanicsBody compositionBone graftBone marrow mesenchymal stem cellCartilageCartilage defect repaiCartilage defect repairCartilage, articularCell differentiationCell infiltrationCell survivalCell viabilityChemical compositionChemistryChondrocyteChondrogenesisChondropathyCollagenCollagen type 1Collagen type 2Collagen type i alpha 1 chainCytologyDecanoatesDecanoic acidDeformatioDifferentiationDrug delivery systemDrug effectFatigueFollow upGene expressionGlycerolGlycosaminoglycan polysulfateHistologyHyaluronic acidMechanical phenomenaMechanicsMesenchymal stem cellMesenchymal stem cellsOsteochondral tissuePoly (glycerol sebacate)Poly(glycerol-sebacate)PolymerPolymerizationPolymersPorosityPrinting, three-dimensionalProceduresRatRatsRegenerationReverse transcription polymerase chain reactionScaffolds (biology)Scanning electron microscopySebacic acidSox9Stem cellsTetrahydrofuranThree dimensional printingTissue engineeringTissue regenerationTissue scaffoldTissue scaffoldsUnclassified drug

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal International Journal Of Biological Macromolecules due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 6/94, thus managing to position itself as a Q1 (Primer Cuartil), in the category Polymer Science. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-12-21:

  • WoS: 3
  • Scopus: 11
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-21:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 25.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 25 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United Kingdom.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (LIU, YUYAO) .

the author responsible for correspondence tasks has been LLORCA MARTINEZ, FCO. JAVIER.

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Awards linked to the item

This work was supported by the Spanish Research Agency through the grant PID2021-124389OB-C21 and the European Research Council (ERC) Advanced Grant n degrees 788753 degrees 788753 (ReCaP) . Ms. Y. Liu acknowledges the support from the China Scholarship Council (CSC No. 202106990026) .
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