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Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Gutierrez-Contreras, RCorresponding Author

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December 19, 2024
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Comparative Analysis of Silk Fibroin Membranes across Cross-Linking Methods: Processing and Characterization

Publicated to: Acs Omega. 9 (37): 38452-38461 - 2024-08-30 9(37), DOI: 10.1021/acsomega.4c02204

Authors:

Gutierrez-Contreras, R; Fernandez-Gutierrez, M; Olalla-Perez, P; De La Hoz, A; Marcos, S
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Affiliations

Inst Opt Consejo Super Invest Cient IO CSIC - Author
Univ Politecn Madrid - Author
Univ Rochester, Flaum Eye Inst, Inst Opt, Ctr Visual Sci - Author
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Abstract

Silk fibroin (SF) extracted from silkworm silk can be transformed into transparent membranes with well-suited physical properties for ophthalmic applications. There is ample literature on the fabrication and characterization of SF-based membranes; however, the use of diverse SF extraction protocols and characterization methods or their settings makes it difficult to compare different silk membrane properties across studies. In this work, we fabricated 10 families of SF-based membranes by physical cross-linking and one non-cross-linked as a control. We evaluated transparency (ranging from 84.5 to 95.3% in the visible spectrum), enzyme stability (from 24 h to 200 days in protease XIV), decomposition temperature (280-290 degrees C), water uptake (40-60%), Young's modulus (8-30 MPa), roughness (1.6-22.7 nm), and FTIR spectra for the secondary structure. We found correlation between water uptake and the Young's modulus (the lower the water uptake, the higher the Young's modulus) and a relationship between membrane stability in protease XIV and the secondary structure of the proteins. Higher surface roughness and faster degradation were found in membranes cross-linked with polyethylene glycol, and conversely, lower roughness and lower degradation were found in methanol, ethanol, or isopropanol crossed-link membranes. This ample compilation of materials and their characterization will aid in the selection of a SF-based material according to the needs of the application.
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Keywords

DegradationDrug-deliveryFibersFilmsHydrationZero hunger

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Acs Omega due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemical Engineering (Miscellaneous).

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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-22:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 14.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 13 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 2 - End hunger, achieve food security and improved nutrition and promote sustainable agriculture, with a probability of 48% according to the mBERT algorithm developed by Aurora University.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (GUTIÉRREZ CONTRERAS, ROCÍO) .

the author responsible for correspondence tasks has been GUTIÉRREZ CONTRERAS, ROCÍO.

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