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Analysis of institutional authors

Palomino-Fernandez, DavidAuthorSeiffert, Alexander PAuthorGómez E.j.AuthorSanchez-Gonzalez, PatriciaCorresponding Author

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January 12, 2025
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Reduced Homogeneous Myocardial [18F]FDG Uptake in Routine PET/CT Studies as an Early Indicator of Chemotherapy-Induced Cardiotoxicity

Publicated to: Applied Sciences-Basel. 14 (24): 11653- - 2024-12-01 14(24), DOI: 10.3390/app142411653

Authors:

Palomino-Fernandez, David; Bueno, Hector; Jimenez-Lopez-Guarch, Carmen; Moreno, Guillermo; Seiffert, Alexander P; Gomez, Enrique J; Gomez-Grande, Adolfo; Sanchez-Gonzalez, Patricia
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Affiliations

Ctr Invest Biomed Red Enfermedades Cardiovasc CIBE, Madrid 28029, Spain - Author
Ctr Nacl Invest Cardiovasc CNIC, Madrid 28029, Spain - Author
Hosp Univ 12 Octubre, Dept Nucl Med, Madrid 28041, Spain - Author
Hosp Univ 12 Octubre, Inst Invest Sanitaria Hosp 12 Octubre Imas12, Madrid 28041, Spain - Author
Hosp Univ 12 Octubre, Inst Invest Sanitaria Imas12, Dept Cardiol, Madrid 28041, Spain - Author
Inst Salud Carlos III, Ctr Invest Biomed Red Bioingn Biomat & Nanomed, Madrid 28029, Spain - Author
Univ Complutense Madrid, Fac Enfermeria Fisioterapia & Podol, Madrid 28040, Spain - Author
Univ Complutense Madrid, Fac Med, Madrid 28040, Spain - Author
Univ Politecn Madrid, Ctr Biomed Technol, Biomed Engn & Telemed Ctr, ETSI Telecomunicac, Madrid 28040, Spain - Author
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Abstract

Cardiotoxicity refers to the damage induced by antineoplastic treatments, leading to various cardiovascular conditions. [F-18]FDG PET radiomics analysis could provide relevant information on early onset changes occurring in cardiac metabolism of chemotherapy-induced cardiotoxicity. Patients' sociodemographic data, cardiovascular risk factors, laboratory parameters, and left ventricle [F-18]FDG PET radiomic features are analyzed. The H-Rad index for the quantification of the heterogeneity of the metabolic uptake patterns is proposed. Statistical analysis is performed by separating patients according to the diagnosis of cancer therapy-related cardiac dysfunction (CTRCD). Baseline, intermediate, and end-of-treatment scans are evaluated as separate groups. Overall, CTRCD+ patients show lower overall mean standardized uptake values (SUVmean) compared to CTRCD- patients, with statistically significant differences between groups only observed in the intermediate PET study (p = 0.025). A total of 34 radiomic features show statistically significant differences between the CTRCD+ and CTRCD- groups in the intermediate imaging studies. In the CTRCD- group, greater overall heterogeneity of metabolic uptake is observed in the intermediate PET image compared to the CTRCD+ groups (p = 0.025). The assessment of CTRCD through [F-18]FDG PET radiomics analysis could be a potential tool for the identification of a predisposition to the later development of cardiac complications after cardiotoxic treatment.
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Keywords

CancerCancer therapy-related cardiac dysfunctionCardiotoxicityDiseasEarly diagnosiEarly diagnosisFdg uptakeMechanismsMetabolismMyocardial metabolismRadiomicsToxicity[ f]fdg pet 18[f-18]fdg pet

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Applied Sciences-Basel due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 50/179, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Engineering, Multidisciplinary. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Engineering (Miscellaneous).

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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-25:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 6.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 5 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 7.
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/88568/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 155
  • Downloads: 43
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (PALOMINO FERNANDEZ, DAVID) and Last Author (SANCHEZ GONZALEZ, PATRICIA).

the author responsible for correspondence tasks has been SANCHEZ GONZALEZ, PATRICIA.

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Awards linked to the item

The project was partially funded by a grant from the Sociedad Espanola de Cardiologia (SEC/FEC-INV-BAS 22/023).
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