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Analysis of institutional authors

Parra-Nieto, JorgeAuthorBaeza, AlejandroCorresponding Author

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April 7, 2025
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Liposomal-Based Nanoarchitectonics as Bispecific T Cell Engagers in Neuroblastoma Therapy

Publicated to: Acs Applied Materials & Interfaces. 17 (8): 11937-11945 - 2025-02-17 17(8), DOI: 10.1021/acsami.5c00633

Authors:

Parra-Nieto, Jorge; Hidalgo, Laura; Marquez-Cantudo, Marta; Garcia-Castro, Javier; Megias, Diego; Ramirez, Manuel; Baeza, Alejandro
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Affiliations

Hosp Infantil Univ Nin~o Jesu?s, Serv Hematol & Oncol Pedia?t, MADRID 28009, Spain - Author
Inst salud Carlos III ISCIII, Adv Opt Microscopy unit, Madrid 28220, Spain - Author
Inst Salud Carlos III, Unidad Biotecnol Celular, Madrid 28220, Spain - Author
Univ Polite?cn Madrid, ETSI Aerona?ut & Espacio, Dept Mat & Prod Aerosp, Madrid 28040, Spain - Author
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Abstract

Neuroblastoma (NB) is an aggressive pediatric solid tumor that lacks efficient treatment. In the past few years, the use of engineered lymphocytes endowed with chimeric antigen receptors (CAR T), which improve their natural search and destroy skills against tumoral cells, has provided a highly valuable strategy to eradicate tumors in a specific and safe manner. Unfortunately, despite the excellent results achieved by these cell-based therapies in liquid tumors, their efficacy in the treatment of solid malignancies is usually modest due to the existence of several biological barriers which compromise their efficacy. Herein, a strategy to guide CAR T toward NB cells based on the use of nanometric bispecific T engagers (NBTEs) is presented. These novel bispecific nanoplatforms are based on liposomes and protocells doubly functionalized with synthetic targeting moieties (para-aminobenzylguanidine and fluorescein) able to selectively bind to membrane cell receptors of NB and anti-FITC CAR T, respectively. The binding process of NBTEs to NB cells was monitored by confocal fluorescence microscopy showing the excellent capacity of these nanodevices to place fluorescence labels on the surface of the malignant cells. Then, NB cells previously incubated in the presence of NBTEs were rapidly detected and destroyed by anti-FITC CAR T, which confirmed the excellent capacity of these nanoplatforms to improve the natural capacity of CAR T to eradicate malignant cells. Finally, the high versatility of the NBTE design and its easy-to-tune nature would allow their rapid application to different types of solid tumors.
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Keywords

Antigen receptorsAntigensBispecific t engagerBispecific t engagersCar tCell cultureCell membranesChimeric antigen receptorDrug-deliveryFluorescence microscopyImmunotherapImmunotherapyLiposomesMalignant cellsNanometricsNanoparticleNeuroblastomaNeuroblastoma cellsNeuroblastomasProtocellsSolid tumorsSupported lipid-bilayersT-cells

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Acs Applied Materials & Interfaces due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 83/460, thus managing to position itself as a Q1 (Primer Cuartil), in the category Materials Science, Multidisciplinary.

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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-21:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 4.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 4 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 32.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).
  • The number of mentions in news outlets: 4 (Altmetric).
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (PARRA NIETO, JORGE) and Last Author (Baeza Garcia, Alejandro).

the author responsible for correspondence tasks has been Baeza Garcia, Alejandro.

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Awards linked to the item

The present work was supported by the Spanish government by the Ministerio de Ciencia e Innovacion, Agencia Espanola de Investigacion, through project PID2022-141917OB-I00, MCIN/AEI/10.13039/501100011033/FEDER, UE. A. A. N., A.B., and M.R. are supported by Asociacion Pablo Ugarte. The authors also thank the National Electron Microscopy Center, UCM for the support with the characterization techniques (AFM and TEM).
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