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Analysis of institutional authors

Luque-Agudo, VeronicaAuthor

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December 17, 2025
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Article
Hybrid Gold

Preventing the harmful biofilm increase on the polylactic-acid/Mg surface by the addition of quercetin

Publicated to: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 335 149241- - 2026-01-01 335(), DOI: 10.1016/j.ijbiomac.2025.149241

Authors:

Navarro-Perez, Maria Luisa; Casares-Lopez, Juan Manuel; Fernandez-Calderon, Maria Coronada; Hierro-Oliva, Margarita Mar; Gonzalez-Martin, Maria Luisa; Gallardo-Moreno, Amparo Maria; Luque-Agudo, Veronica
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Affiliations

Ctr Invest Biomed Red Bioingn Biomat & Nanomed CIB, Badajoz 06006, Spain - Author
Inst Univ Invest Biosanit Extremadura INUBE, Badajoz 06006, Spain - Author
Univ Extremadura, Fac Ciencias, Dept Fis Aplicada, Badajoz 06006, Spain - Author
Univ Extremadura, Fac Med & Ciencias Salud, Dept Ciencias Biomed, Badajoz 06006, Spain - Author
Univ Politecn Madrid, Escuela Tecn Super Ingn Montes Forestal & Medio Na, Dept Sistemas & Recursos Nat, Madrid 28040, Spain - Author
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Abstract

Biodegradable composites with antimicrobials properties designed to reduce biofilm formation can sometimes produce the opposite effect to that expected. This is what happened with the antibacterial response of the biomaterial polylactic acid (PLA) doped with Mg: previous studies have shown that Mg is excellent for reducing early biofilm but enhances biofilm after 24 h. For this reason, a natural dopant, quercetin (Qr) is proposed in this work to prepare PLA/Mg/Qr matrices which not only prevent the increase in biofilm formation but also reduce it effectively. PLA crystallinity affects both the mechanical properties and the distribution of dopants inside the matrix and influences the degradation and release rate of the embedded compounds: a semicrystalline state places the dopants closer to the surface, it hardens less with time than the amorphous one, and it results in a higher release of the active compounds and a greater reduction of biofilm. The antibacterial character of Qr comes from its degradation products since, due to its high chemical instability, these derivatives are the ones that appear in the physiological-like environment after releasement. Exposure of the PLA/Mg/Qr matrix to physiological environments also alters its surface physicochemical properties, thus disfavouring bacterial colonization on the material. Therefore, the new sustainable antimicrobial biocomposite PLA/Mg/Qr is able to combine mechanical enhancement with antimicrobial performance.
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Keywords

AntibacterialBiofilmCompositeDegradationNanoparticlesPlaPolylactic acidQuercetin

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2026, it was in position 6/94, thus managing to position itself as a Q1 (Primer Cuartil), in the category Polymer Science. Notably, the journal is positioned above the 90th percentile.

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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-27:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 6.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 6 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/92488/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 38
  • Downloads: 36
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (LUQUE AGUDO, VERONICA).

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Awards linked to the item

This work is part of the projects PID2022-140422OB-I00 and TED2021-131345B-I00 funded by MCIN/AEI/10.13039/501100011033/and FEDER "Una manera de hacer Europa". Goniometry and AFM measurements were performed by the ICTS "NANBIOSIS," specifically by the U16 Unit: "Surface Characterization and Bacterial Colonization" of the CIBER in Bioengineering, Biomaterials and Nano-medicine (CIBER-BBN) . We also appreciate the technical and human support provided by the Facility of Analysis and Characterization of Solids and Surfaces of SAIUEx for the FT-IR, DSC and SEM measurements, which is financed by UEX, Junta de Extremadura, MICINN, FEDER, and FSE. Special appreciation is extended to James McCue for assistance in language editing.
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