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Pagan, JosueAuthorAyala, José LuisAuthorGalvez-Goicuria, JavierAuthor

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January 21, 2026
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Influence of Clinical and Demographic Variables on the Characteristics of Migraine Attacks

Publicated to: REVISTA DE NEUROLOGIA. 80 (11): PMID 7706841- - 2025-12-23 80(11), DOI: 10.31083/RN44755

Authors:

Quintas, Sonia; Sanchez, Natalia Aranda; Gonzalez-Martinez, Alicia; Campos, Alba Vieira; Pagan, Josue; Ayala, Jose Luis; Galvez-Goicuria, Javier; Sobrado, Monica; Vivancos, Jose; Gago-Veiga, Ana Beatriz
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Affiliations

Brainguard SL, Madrid 28223, Spain - Author
Hosp Univ La Princesa, Serv Neurol, Madrid 28006, Spain - Author
Inst Invest Sanitaria Princesa, Madrid 28006, Spain - Author
Univ Autonoma Madrid, Hosp Univ La Princesa, Fac Med, Madrid 28029, Spain - Author
Univ Complutense Madrid, Dept Arquitectura Comp & Automat, Madrid 28040, Spain - Author
Univ Politecn Madrid, Ctr Computat Stimulat, Campus Montegancedo, Boadilla Del Monte 28223, Spain - Author
Univ Politecn Madrid, Dept Ingn Elect, Madrid 28031, Spain - Author
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Abstract

Introduction: Migraine diagnosis relies on clinical criteria that encompass various pain features and associated symptoms, which can vary widely across patients. The aim of this study was to analyze the potential association between sociodemographic factors and the characteristics of migraine attacks.Methods: We conducted an observational longitudinal study with prospective and real-time data collection using a custom-designed smartphone application. Clinical features and accompanying symptoms of each attack were recorded.Results: A total of 377 migraine attacks from 51 patients were analyzed. Headache intensity was higher in women (p = 0.038), in those with lower cognitive reserve (p = 0.049), and in patients with higher Headache Impact Test-6 (HIT-6) scores (p = 0.020). Hemicranial pain was more common in patients with a longer disease duration (p = 0.028) and female sex was associated with a higher frequency of nausea (p = 0.034).Conclusions: Prospective and real-time recording of migraine attacks provides added value by more accurately capturing their clinical variability. Our findings suggest that sociodemographic variables influence attack characteristics, supporting the need for more personalized therapeutic approaches.
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Keywords

AdultAgeCognitionCognitive reserveFemaleHeadache impactHormonesHumansLongitudinal studiesMaleMiddle agedMigraineMigraine disordersMigraine with auraMobile applicationsPainPopulationPrevalenceProspective studiesSex factorsSex-differencesSociodemographic factorsYoung adult

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal REVISTA DE NEUROLOGIA, and although the journal is classified in the quartile Q4 (Agencia WoS (JCR)), its regional focus and specialization in Clinical Neurology, give it significant recognition in a specific niche of scientific knowledge at an international level.

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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-11:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 1.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 1 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/93934/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 20
  • Downloads: 4
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Project objectives

El estudio persigue los siguientes objetivos: analizar la asociación entre variables sociodemográficas y las características de los ataques de migraña; evaluar la intensidad del dolor cefálico en función del sexo, reserva cognitiva y puntuaciones en el Headache Impact Test-6; determinar la relación entre la duración de la enfermedad y la presencia de dolor hemicraneal; caracterizar la frecuencia de náuseas según el sexo; y valorar la utilidad del registro prospectivo y en tiempo real de los ataques mediante una aplicación móvil para capturar la variabilidad clínica de la migraña. Estos objetivos permiten avanzar hacia enfoques terapéuticos más personalizados y adaptados a las diferencias individuales.
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Most relevant results

El estudio analizó la influencia de variables clínicas y sociodemográficas en las características de las migrañas mediante un seguimiento prospectivo y en tiempo real de 377 ataques en 51 pacientes. Los resultados más relevantes indican que la intensidad del dolor de cabeza fue significativamente mayor en mujeres (p = 0.038), en pacientes con menor reserva cognitiva (p = 0.049) y en aquellos con puntuaciones elevadas en el Headache Impact Test-6 (HIT-6) (p = 0.020). Además, el dolor hemicraneal se asoció con una mayor duración de la enfermedad (p = 0.028), y la frecuencia de náuseas fue superior en mujeres (p = 0.034). Estos hallazgos evidencian la influencia de variables sociodemográficas en la presentación clínica de la migraña.
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Awards linked to the item

Agradecemos a los pacientes por su dedicacion.
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