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Analysis of institutional authors

Fernandez Pacios, LuisAuthorGarrido-Arandia, M.AuthorDiaz-Perales, A.Corresponding Author

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June 9, 2019
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Allergenic Characterization of New Mutant Forms of Pru p 3 as New Immunotherapy Vaccines

Publicated to: Clinical and Developmental Immunology. 2013 (385615): 385615- - 2013-12-16 2013(385615), DOI: 10.1155/2013/385615

Authors:

Gómez-Casado, C; Garrido-Arandia, M; Gamboa, P; Blanca-López, N; Canto, G; Varela, J; Cuesta-Herranz, J; Pacios, LF; Díaz-Perales, A; Tordesillas, L
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Affiliations

CSIC, Ctr Invest Biol, Serv Quim Prot - Author
Ctr Biotecnol & Genom Plantas UPM INIA - Author
Fdn Jimenez Diaz, IIS Serv Alergia - Author
Hosp Basurto, Serv Alergia - Author
Hosp Infanta Leonor, Serv Alergia - Author
UPM, ETS Ingenieros Montes, Dept Biotecnol - Author
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Abstract

Nowadays, treatment of food allergy only considered the avoidance of the specific food. However, the possibility of cross-reactivity makes this practice not very effective. Immunotherapy may exhibit as a good alternative to food allergy treatment. The use of hypoallergenic molecules with reduced IgE binding capacity but with ability to stimulate the immune system is a promising tool which could be developed for immunotherapy. In this study, three mutants of Pru p 3, the principal allergen of peach, were produced based on the described mimotope and T cell epitopes, by changing the specific residues to alanine, named as Pru p 3.01, Pru p 3.02, and Pru p 3.03. Pru p 3.01 showed very similar allergenic activity as the wild type by in vitro assays. However, Pru p 3.02 and Pru p 3.03 presented reduced IgE binding with respect to the native form, by in vitro, ex vivo, and in vivo assays. In addition, Pru p 3.03 had affected the IgG4 binding capacity and presented a random circular dichroism, which was reflected in the nonrecognition by specific antibodies anti-Pru p 3. Nevertheless, both Pru p 3.02 and Pru p 3.03 maintained the binding to IgG1 and their ability to activate T lymphocytes. Thus, Pru p 3.02 and Pru p 3.03 could be good candidates for potential immunotherapy in peach-allergic patients.
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Keywords

B-cell epitopesDouble-blindExpressionGrass-pollen allergenImmunoglobulin-eLipid-transfer proteinMajor peach allergenPotential useReactivityVaccination

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Clinical and Developmental Immunology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2013, it was in position 67/144, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Immunology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-27:

  • WoS: 11
  • Scopus: 9
  • Europe PMC: 3
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-27:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 30.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 30 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 37.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).
  • The number of mentions in news outlets: 5 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/26278/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 408
  • Downloads: 282
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Gomez-Casado, C.) and Last Author (Tordesillas, L.).

the author responsible for correspondence tasks has been DIAZ PERALES, ARACELI.

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Awards linked to the item

Financial support from the Ministerio de Ciencia e Innovacion (Grant BIO2009-07050) and the Instituto de Salud Carlos III, RETICS 2007 (RD07/0064/03), Spain, are acknowledged. C. Gomez-Casado and L. Tordesillas were supported by training grants from the Spanish Government (FPI and FPU programmes, MEC, resp.).
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