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Analysis of institutional authors

Strange, B. A.Author

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June 9, 2019
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Dopamine receptor 4 promoter polymorphism modulates memory and neuronal responses to salience

Publicated to: NEUROIMAGE. 84 922-931 - 2014-01-01 84(), DOI: 10.1016/j.neuroimage.2013.09.065

Authors:

Strange, BA; Gartmann, N; Brenninkmeyer, J; Haaker, J; Reif, A; Kalisch, R; Büchel, C
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Affiliations

Grupo de Bioingeniería y Telemedicina. Universidad Politécnica de Madrid - Author
Tech Univ Madrid, Ctr Biomed Technol, Lab Clin Neurosci, Madrid, Spain - Author
Univ Med Ctr Hamburg Eppendorf, Dept Syst Neurosci, Hamburg, Germany - Author
Univ Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany - Author
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Abstract

Animal models and human functional imaging data implicate the dopamine system in mediating enhanced encoding of novel stimuli into human memory. A separate line of investigation suggests an association between a functional polymorphism in the promoter region for the human dopamine 4 receptor gene (DRD4) and sensitivity to novelty. We demonstrate, in two independent samples, that the -521C>T DRD4 promoter polymorphism determines the magnitude of human memory enhancement for contextually novel, perceptual oddball stimuli in an allele dose-dependent manner. The genotype-dependent memory enhancement conferred by the C allele is associated with increased neuronal responses during successful encoding of perceptual oddballs in the ventral striatum, an effect which is again allele dose-dependent. Furthermore, with repeated presentations of oddball stimuli, this memory advantage decreases, an effect mirrored by adaptation of activation in the hippocampus and substantia nigra/ventral tegmental area in C carriers only. Thus, a dynamic modulation of human memory enhancement for perceptually salient stimuli is associated with activation of a dopaminergic-hippocampal system, which is critically dependent on a functional polymorphism in the DRD4 promoter region. (C) 2013 Elsevier Inc. All rights reserved.
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Keywords

dopaminedrd4 promoter polymorphismhippocampusmemorynoveltyAdultBrainDifferential amygdala activationDopamineDrd4 promoter polymorphismEpisodic memoryExon-iiiFmriGenetic-variationGenotypeHippocampusHumansImage processing, computer-assistedMagnetic resonance imagingMaleMemoryMiddle agedNo associationNoveltyNovelty-seekingPersonality-traitsPolymorphism, single nucleotidePrefrontal cortexPromoter regions, geneticReceptors, dopamine d4StimuliThe-521 c/t polymorphismYoung adult

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal NEUROIMAGE due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2014, it was in position 24/252, thus managing to position itself as a Q1 (Primer Cuartil), in the category Neurosciences.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-25:

  • Google Scholar: 15
  • WoS: 11
  • Scopus: 11
  • Europe PMC: 4
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-25:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 51 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/26430/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 466
  • Downloads: 592
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Germany.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (STRANGE, BRYAN) .

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Awards linked to the item

This work was supported by the Federal Ministry of Education and Research, Deutsche Forschungsgemeinschaft (DFG KA1623/3-1 for NG, JB, RK, TRR 58 B3 for CB and Z02 to AR) and the EU (LSHM-CT-2007-037286 and ERC-2010-AdG 20100407 for CB). BS is supported by a Marie Curie Career Integration grant (FP7-PEOPLE-2011-CIG 304248) and grant SAF2011-27766 from the Spanish Ministry of Science and Innovation. We thank Nicole Doring and Frauke Fassbinder for excellent technical assistance as well as the volunteers for participating in this study.
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