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Analysis of institutional authors

Del Pozo, FranciscoCorresponding Author

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June 9, 2019
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Synchronization during an internally directed cognitive state in healthy aging and mild cognitive impairment: a MEG study

Publicated to: AGE. 36 (3): 1389-1406 - 2014-06-01 36(3), DOI: 10.1007/s11357-014-9643-2

Authors:

López, ME; Garcés, P; Cuesta, P; Castellanos, NP; Aurtenetxe, S; Bajo, R; Marcos, A; Montenegro, M; Yubero, R; del Pozo, F; Sancho, M; Maestú, F
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Affiliations

Ayuntamiento Madrid, Madrid Salud, Memory Decline Prevent Ctr, Madrid 28006, Spain - Author
Ctr Biomed Technol CTB, Madrid 28223, Spain - Author
San Carlos Univ Hosp, Dept Geriatr, Madrid 28040, Spain - Author
San Carlos Univ Hosp, Dept Neurol, Madrid 28040, Spain - Author
UCM UPM, Ctr Biomed Technol CTB, Lab Cognit & Computat Neurosci, Madrid 28223, Spain - Author
UCM UPM, Madrid 28223, Spain - Author
Univ Complutense Madrid, Dept Basic Psychol 2, E-28040 Madrid, Spain - Author
Univ Complutense Madrid, Dept Fis Aplicada 3, Fac Fis, E-28040 Madrid, Spain - Author
Univ Int La Rioja UNIR, Dept Math, Logrono, La Rioja, Spain - Author
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Abstract

Mild cognitive impairment (MCI) is a stage between healthy aging and dementia. It is known that in this condition the connectivity patterns are altered in the resting state and during cognitive tasks, where an extra effort seems to be necessary to overcome cognitive decline. We aimed to determine the functional connectivity pattern required to deal with an internally directed cognitive state (IDICS) in healthy aging and MCI. This task differs from the most commonly employed ones in neurophysiology, since inhibition from external stimuli is needed, allowing the study of this control mechanism. To this end, magnetoencephalographic (MEG) signals were acquired from 32 healthy individuals and 38 MCI patients, both in resting state and while performing a subtraction task of two levels of difficulty. Functional connectivity was assessed with phase locking value (PLV) in five frequency bands. Compared to controls, MCIs showed higher PLV values in delta, theta, and gamma bands and an opposite pattern in alpha, beta, and gamma bands in resting state. These changes were associated with poorer neuropsychological performance. During the task, this group exhibited a hypersynchronization in delta, theta, beta, and gamma bands, which was also related to a lower cognitive performance, suggesting an abnormal functioning in this group. Contrary to controls, MCIs presented a lack of synchronization in the alpha band which may denote an inhibition deficit. Additionally, the magnitude of connectivity changes rose with the task difficulty in controls but not in MCIs, in line with the compensation-related utilization of neural circuits hypothesis (CRUNCH) model.
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Keywords

Alzheimers-diseaseBrain-functionCoherenceCrunchEeg-alpha synchronizationFunctional connectivityHippocampal atrophyInternally directed cognitive state (idics)MegMental calculationMild cognitive impairmentOlder-adultsResearch criteriaWorking-memory task

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal AGE due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2014, it was in position 14/50, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Geriatrics & Gerontology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-26:

  • WoS: 27
  • Scopus: 31
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-26:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 85 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/35590/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 528
  • Downloads: 285
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Leadership analysis of institutional authors

the author responsible for correspondence tasks has been POZO GUERRERO, FRANCISCO DEL.

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Awards linked to the item

This study was supported by two projects PSI2009-14415-C03-01 and PSI2012-38375-C03-01 from the Spanish Ministry of Science and Economy, a predoctoral fellowship from the Ministry of Education (FPU AP-2008-00175), a PICATA predoctoral fellowship of the Moncloa Campus of International Excellence (UCM-UPM), a predoctoral fellowship from the Spanish Ministry of Science and Innovation (BES-2010-036469), and a predoctoral fellowship from the Basque Government.
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