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Analysis of institutional authors

Alonso-Calvo, RaulCorresponding AuthorPerez-Rey, DavidAuthorParaiso-Medina, SergioAuthor

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June 9, 2019
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Enabling semantic interoperability in multi-centric clinical trials on breast cancer

Publicated to: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE. 118 (3): 322-329 - 2015-03-01 118(3), DOI: 10.1016/j.cmpb.2015.01.003

Authors:

Alonso-Calvo, R; Perez-Rey, D; Paraiso-Medina, S; Claerhout, B; Hennebert, P; Bucur, A
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Affiliations

Custodix NV, St Martens Latem, Belgium - Author
Inst Jules Bordet, B-1000 Brussels, Belgium - Author
Philips Res Europe, Eindhoven, Netherlands - Author
Univ Politecn Madrid, Fac Informat, DIA, E-28660 Madrid, Spain - Author
Univ Politecn Madrid, Fac Informat, DLSIIS, Biomed Informat Grp, E-28660 Madrid, Spain - Author
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Abstract

Background and objectives: Post-genomic clinical trials require the participation of multiple institutions, and collecting data from several hospitals, laboratories and research facilities. This paper presents a standard-based solution to provide a uniform access endpoint to patient data involved in current clinical research. Methods: The proposed approach exploits well-established standards such as HL7 v3 or SPARQL and medical vocabularies such as SNOMED CT, LOINC and HGNC. A novel mechanism to exploit semantic normalization among HL7-based data models and biomedical ontologies has been created by using Semantic Web technologies. Results: Different types of queries have been used for testing the semantic interoperability solution described in this paper. The execution times obtained in the tests enable the development of end user tools within a framework that requires efficient retrieval of integrated data. Conclusions: The proposed approach has been successfully tested by applications within the INTEGRATE and EURECA EU projects. These applications have been deployed and tested for: (i) patient screening, (ii) trial recruitment, and (iii) retrospective analysis; exploiting semantically interoperable access to clinical patient data from heterogeneous data sources. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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Keywords

clinical research informaticsclinical trialsdata integrationhl7snomed ctBreast neoplasmsClinical research informaticsClinical trialsClinical trials as topicComputational biologyData integrationDatabase management systemsDatabases, factualFemaleHl7HumansInformation storage and retrievalInternetMulticenter studies as topicSemantic interoperabilitySnomed ctSnomed-ctTerminologyTerminology as topic

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2015, it was in position 10/20, thus managing to position itself as a Q1 (Primer Cuartil), in the category Medical Informatics.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-25:

  • WoS: 11
  • Scopus: 11
  • Europe PMC: 6
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-25:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 82 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/87584/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 175
  • Downloads: 1
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Belgium; Netherlands.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (ALONSO CALVO, RAUL) .

the author responsible for correspondence tasks has been ALONSO CALVO, RAUL.

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Awards linked to the item

The presented work has been partially funded by the European Commission through the INTEGRATE (FP7-ICT-2009-6-270253) and the EURECA (FP7-ICT-2011-288048) project, and also it has been funded by the Ministry of Health of the Spanish Government under the grant no. PI13/02020.
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