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Analysis of institutional authors

Dreyer, IngoAuthor

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June 9, 2019
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Outward Rectification of Voltage-Gated K+ Channels Evolved at Least Twice in Life History

Publicated to: PLoS One. 10 (9): e0137600- - 2015-09-10 10(9), DOI: 10.1371/journal.pone.0137600

Authors:

Riedelsberger, J; Dreyer, I; Gonzalez, W
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Affiliations

Univ Potsdam, Inst Biochem & Biol - Author
Univ Talca, CBSM - Author

Abstract

Voltage-gated potassium (K+) channels are present in all living systems. Despite high structural similarities in the transmembrane domains (TMD), this K+ channel type segregates into at least two main functional categories-hyperpolarization-activated, inward-rectifying (Kin) and depolarization-activated, outward-rectifying (Kout) channels. Voltage-gated K+ channels sense the membrane voltage via a voltage-sensing domain that is connected to the conduction pathway of the channel. It has been shown that the voltage-sensing mechanism is the same in Kin and Kout channels, but its performance results in opposite pore conformations. It is not known how the different coupling of voltage-sensor and pore is implemented. Here, we studied sequence and structural data of voltage-gated K+ channels from animals and plants with emphasis on the property of opposite rectification. We identified structural hotspots that alone allow already the distinction between Kin and Kout channels. Among them is a loop between TMD S5 and the pore that is very short in animal Kout, longer in plant and animal Kin and the longest in plant Kout channels. In combination with further structural and phylogenetic analyses this finding suggests that outward-rectification evolved twice and independently in the animal and plant kingdom.
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Keywords

ActivationAnimalsBiological evolutionCluster analysisDatabases, geneticExpressionInward rectificationMechanismModelsModels, molecularPlantsPotassium channelPotassium channels, voltage-gatedProtein conformationProtein interaction domains and motifsRequiresS4-s5 linkerSensorStructure-activity relationshipTransport

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal PLoS One due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2015, it was in position 11/62, thus managing to position itself as a Q1 (Primer Cuartil), in the category Multidisciplinary Sciences.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-26:

  • WoS: 9
  • Scopus: 11
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-26:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 29.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 29 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/41450/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 413
  • Downloads: 193
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Chile; Germany.

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Awards linked to the item

This work was supported by grants from the Chilean Fondo Nacional de Desarrollo Cientifico y Tecnologico (http://www.conicyt.cl/fondecyt) to JR (No. 3150173) and WG (No. 1140624), and by the Chilean Comision Nacional de Investigacion Cientifica y Tecnologica (http://www.conicyt.cl) to JR and WG (Anillo ACT-1104). ID was supported by grants of the Deutsche Forschungsgemeinschaft (DR430/8-1) (http://www.dfg.de/) and Marie Curie Career Integration Grant of the European Union (FP7-PEOPLE-2011-CIG No. 303674-Regopoc) (http://ec.europa.eu/research/mariecurieactions/about-mca/actions/cig/index_en.htm). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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