{rfName}
Lo

Indexed in

License and Use

Icono OpenAccess

Citations

51

Altmetrics

Analysis of institutional authors

Fernandez-Garcia, LauraAuthorRamos, MilagrosAuthorGonzalez-Nieto, DanielAuthor

Share

June 9, 2019
Publications
>
Article
Sí

Long-term dynamics of somatosensory activity in a stroke model of distal middle cerebral artery oclussion

Publicated to: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 36 (3): 606-620 - 2016-03-01 36(3), DOI: 10.1177/0271678X15606139

Authors:

Barios, JA; Pisarchyk, L; Fernandez-Garcia, L; Barrio, LC; Ramos, M; Martinez-Murillo, R; Gonzalez-Nieto, D
[+]

Affiliations

Biomed Res Networking Ctr Bioengn Biomat & Nanome, Madrid, Spain - Author
CSIC, Inst Cajal, Dept Mol Cellular & Dev Neurobiol, E-28002 Madrid, Spain - Author
Hosp Univ Ramon & Cajal, Unit Expt Neurol, IRYCIS, Madrid, Spain - Author
Univ Politecn Madrid, Unit Cellular & Anim Models, Expt Neurol Lab, Ctr Biomed Technol, Campus Montegancedo S-N, Madrid 28223, Spain - Author
See more

Abstract

A constant challenge in experimental stroke is the use of appropriate tests to identify signs of recovery and adverse effects linked to a particular therapy. In this study, we used a long-term longitudinal approach to examine the functional brain changes associated with cortical infarction in a mouse model induced by permanent ligation of the middle cerebral artery (MCA). Sensorimotor function and somatosensory cortical activity were evaluated with fault-foot and forelimb asymmetry tests in combination with somatosensory evoked potentials. The stroke mice exhibited both long-term deficits in the functional tests and impaired responses in the infarcted and intact hemispheres after contralateral and ipsilateral forepaw stimulation. In the infarcted hemisphere, reductions in the amplitudes of evoked responses were detected after contralateral and ipsilateral stimulation. In the intact hemisphere, and similar to cortical stroke patients, a gradual hyperexcitability was observed after contralateral stimulation but no parallel evidence of a response was detected after ipsilateral stimulation. Our results suggest the existence of profound and persistent changes in the somatosensory cortex in this specific mouse cortical stroke model. The study of evoked potentials constitutes a feasible and excellent tool for evaluating the fitness of the somatosensory cortex in relation to functional recovery after preclinical therapeutic intervention.
[+]

Keywords

behaviorsomatosensory evoked potentialsBehaviorBrain ischemiaCortexFocal ischemiaFunctional recoveryIschemic-strokeMedian nerveMotor evoked-potentialsNeocortical infarctionOcclusionRat-brainSomatosensory evoked potentialsStroke neuroprotection and repair

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2016, it was in position 15/70, thus managing to position itself as a Q1 (Primer Cuartil), in the category Hematology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-24:

  • Google Scholar: 18
  • WoS: 13
  • Scopus: 13
  • Europe PMC: 6
[+]

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-24:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 76 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/41082/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 502
  • Downloads: 322
[+]

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Barios, Juan A.) and Last Author (GONZALEZ NIETO, DANIEL).

[+]

Awards linked to the item

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Community of Madrid Grant Neurotec-S2010/BMD-2460 (to D.G.-N.), from Mexican National Committee of Science and Technology (CONACyT to L.P) and funds from the Spanish Ministry of Economy and Competitiveness (Consolider CSD2008-00005 and BFU2013-33821 to L.C.B.). We would like to thank Soledad Martinez for the excellent technical assistance. We also express our gratitude to Carlos Paino for his assistance with the histological images.
[+]