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Analysis of institutional authors

Rodríguez-Romo G.Author

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The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts

Publicated to:Age. 36 (2): 933-943-943 - 2014-01-01 36(2), DOI: 10.1007/s11357-013-9593-0

Authors: Pinos, Tomas; Fuku, Noriyuki; Camara, Yolanda; Arai, Yasumichi; Abe, Yukiko; Rodriguez-Romo, Gabriel; Garatachea, Nuria; Santos-Lozano, Alejandro; Miro-Casas, Elisabet; Ruiz-Meana, Marisol; Otaegui, Imanol; Murakami, Haruka; Miyachi, Motohiko; Garcia-Dorado, David; Hinohara, Kunihiko; Andreu, Antoni L; Kimura, Akinori; Hirose, Nobuyoshi; Lucia, Alejandro

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Abstract

The rs1333049 (G/C) polymorphism located on chromosome 9p21.3 is a candidate to influence extreme longevity owing to its association with age-related diseases, notably coronary artery disease (CAD). We compared allele/genotype distributions of rs1333049 in cases (centenarians) and controls (younger adults, without (healthy) or with CAD) in two independent cohorts: Spanish (centenarians: n?=?152, 128 women, 100-111 years; healthy controls: n?=?343, 212 women, age <50 years; CAD controls: n?=?98, 32 women, age ?65 years) and Japanese (centenarians: n?=?742, 623 women, 100-115 years; healthy controls: n?=?920, 511 women, < 60 years; CAD controls: n?=?395, 45 women, age ?65 years). The frequency of the "risk" C-allele tended to be lower in Spanish centenarians (47.0 %) than in their healthy (52.9 %, P?=?0.088) or CAD controls (55.1 %, P?=?0.078), and significant differences were found in genotype distributions (P?=?0.034 and P?=?0.045), with a higher frequency of the GG genotype in cases than in both healthy and CAD controls as well as a lower proportion of the CG genotype compared with healthy controls. In the Japanese cohort, the main finding was that the frequency of the C-allele did not differ between centenarians (46.4 %) and healthy controls (47.3 %, P?=?0.602), but it was significantly lower in the former than in CAD controls (57.2 %, P?

Keywords

Cdkn2aCdkn2bCentenariansCoronary artery diseaseGenetics

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Age due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2014, it was in position 14/50, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Geriatrics & Gerontology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.05, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-02, the following number of citations:

  • WoS: 4
  • Scopus: 12
  • Europe PMC: 6
  • Google Scholar: 16
  • OpenCitations: 10

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 40.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 40 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 44.258.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/84208/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 63
  • Downloads: 6

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Japan.