June 27, 2019
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Automated detection of neutropenia using noninvasive video microscopy of superficial capillaries

Publicated to: AMERICAN JOURNAL OF HEMATOLOGY. 94 (8): E219-E222 - 2019-08-01 94(8), DOI: 10.1002/ajh.25516

Authors:

Pablo-Trinidad, A; Butterworth, I; Ledesma-Carbayo, MJ; Vettenburg, T; Sánchez-Ferro, A; Soenksen, L; Durr, NJ; Muñoz-Barrutia, A; Cerrato, C; Humala, K; Urdiol, MF; Del Rio, C; Valles, B; Chen, YB; Hochberg, EP; Castro-González, C; Bourquard, A
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Affiliations

Carlos III Univ Madrid, Dept Bioengn & Aerosp Engn, Madrid, Spain - Author
CIBER BBN, Madrid, Spain - Author
Harvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02115 USA - Author
Harvard Medical School - Author
Hosp Univ La Paz, Dept Hematol, Madrid, Spain - Author
Hospital Universitario La Paz - Author
Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD USA - Author
Johns Hopkins University - Author
Leuko Labs Inc, Cambridge, MA 02139 USA - Author
Leuko Labs Inc. - Author
Massachusetts Institute of Technology - Author
MIT, Dept Mech Engn, Cambridge, MA 02139 USA - Author
MIT, Elect Res Lab, Cambridge, MA 02139 USA - Author
Univ Politecn Madrid, Biomed Image Technol, Madrid, Spain - Author
Universidad Carlos III de Madrid - Author
Universidad Politécnica de Madrid - Author
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Abstract

Cancer patients undergoing cytotoxic chemotherapy are at elevated risk of developing serious infections. The risk of developing these infections increases when white blood cell (WBC) count, particularly the absolute neutrophil counts (ANC), are reduced. This reduction in neutrophil counts, the most abundant white-blood-cell subtype, is referred to as neutropenia, with these infection episodes termed febrile neutropenia (FN). Patients have a high risk of developing FN during sustained severe neutropenia (ANC< 500/?L), which is a common side effect of cytotoxic chemotherapies. FN occurs frequently, currently in approximately one in six of all chemotherapy patients, and it is associated with a high rate of mortality, where 11% of patients die after one or several hospitalizations. In the US alone, the associated cost due to such hospitalizations accounts for $2.7 B dollars annually, contributing to up to 40% of the total cost of cancer treatments.
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Keywords

CapillariesChemotherapyHumansImage processing, computer-assistedMicroscopy, videoNeutropeniaSensitivity and specificity

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal AMERICAN JOURNAL OF HEMATOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position 8/76, thus managing to position itself as a Q1 (Primer Cuartil), in the category Hematology. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-27:

  • Google Scholar: 5
  • WoS: 14
  • Scopus: 14
  • Europe PMC: 3
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-27:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 24.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 24 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 42.
  • The number of mentions in news outlets: 6 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/64276/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 307
  • Downloads: 211
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Timor-Leste; United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (PABLO TRINIDAD, ALBERTO) and Last Author (BOURQUARD, AURÉLIEN).

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