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May 15, 2020
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Postnatal exposure to low doses of Chlorpyrifos induces long-term effects on 5C-SRTT learning and performance, cholinergic and GABAergic systems and BDNF expression

Publicated to: EXPERIMENTAL NEUROLOGY. 330 (113356): 113356-113356 - 2020-08-01 330(113356), DOI: 10.1016/j.expneurol.2020.113356

Authors:

Perez-Fernandez C, Morales-Navas M, Guardia-Escote L, Colomina MT, Giménez E, Sánchez-Santed F
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Affiliations

Department of Biology and Geology, University of Almería, Ctra. Sacramento, s/n, 04120 Almería, Spain. Electronic address: estela@ual.es. - Author
Department of Psychology and Health Research Center (CEINSA), Laboratory of Psychobiology, University of Almería CeiA3, 04120, Carretera de Sacramento s/n, La Cañada de San Urbano, Almería, Spain. - Author
Department of Psychology and Health Research Center (CEINSA), Laboratory of Psychobiology, University of Almería CeiA3, 04120, Carretera de Sacramento s/n, La Cañada de San Urbano, Almería, Spain. Electronic address: cpf603@ual.es. - Author
Department of Psychology and Health Research Center (CEINSA), Laboratory of Psychobiology, University of Almería CeiA3, 04120, Carretera de Sacramento s/n, La Cañada de San Urbano, Almería, Spain. Electronic address: fsanchez@ual.es. - Author
Department of Psychology and Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, 43007, Carretera de Valls, s/n, Tarragona, Spain. Electronic address: laia.guardia@urv.cat. - Author
Department of Psychology and Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, 43007, Carretera de Valls, s/n, Tarragona, Spain. Electronic address: mariateresa.colomina@urv.cat. - Author
Research in Neurobehavior and Health (NEUROLAB), Universitat Rovira i Virgili, Tarragona, Spain - Author
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Abstract

Alterations in attention and inhibitory control are common features in several neurological disorders. Environmental factors such as exposure to pesticides have been linked to their appearance. Chlorpyrifos (CPF) is the most widely used organophosphate compound in the world. CPF exposure during development seems to be critical for later behavioral and molecular disruptions during adult ages, although this depends on the specific period of development, where the preweaning period is the least studied. Despite the abundant empirical work made in the last decades on developmental CPF exposure, the systematic study of this on attention is sparse, and nonexistent concerning inhibitory control, without a single study on preweaning developmental stages. The present research explored the effects of the exposure to low doses of CPF that do not elicit a significant inhibition of the Cholinesterases during this developmental period on rats' behavior in the five-choice serial reaction time task. Behavioral manipulations (inter-trial interval and stimulus duration), pharmacological manipulations (cholinergic and GABAergic drugs) and brain gene expression analyses were also conducted. Exposure to CPF decreased the locomotor activity and enhanced the learning profile of the female rats, increased the impulsive rates, unmasked by a longer inter-trial interval, hypo-sensitized the cholinergic system and down-regulated the mRNA expression levels of the brain-derived neurotrophic factor in the dorsal striatum of the male rats. This happened without significant inhibition of the brain Acetylcholinesterase. All this new information corroborates that the exposure to a common pesticide at low doses during a key, but under-explored developmental period importantly affects different behaviors, neurotransmitter systems, and molecules that are altered in the main neurological disorders observed nowadays.Copyright © 2020. Published by Elsevier Inc.
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Keywords

AttentionBehavioral consequencesBrain-derived neurotrophic factorChlorpyrifosDevelopmental exposureGood health and well-beingInhibitory controlInsecticide chlorpyrifosLearningLocomotor activityMethyl parathion exposureNeurobehavioral performanceNeurotrophic factorOrganophosphate pesticide exposureReaction-time-taskRepeated acquisitionSustained attention

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal EXPERIMENTAL NEUROLOGY due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Developmental Neuroscience.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-26:

  • Open Alex: 18
  • WoS: 3
  • Scopus: 17
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-26:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 43.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 43 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.
  • The number of mentions on the social network X (formerly Twitter): 5 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/86626/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 129
  • Downloads: 35
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 3 - Ensure healthy lives and promote well-being for all at all ages, with a probability of 57% according to the mBERT algorithm developed by Aurora University.
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Awards linked to the item

The authors are grateful to Dra Maria Cabre, Dr. Jordi Blanco, Dra Pia Basaure and Mr. Jose Mata for their initial help in both molecular and behavioral protocols. The present study was supported by two grants from the Ministerio de Economia y Competitividad, Spanish Government and the Fondo Europeo de Desarrollo Regional (MINECO-FEDER). Grant numbers: PSI2017-86847-C2-1-R MINECO-FEDER and PSI2017-86847-C2-2-R.
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