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Analysis of institutional authors

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August 15, 2022
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Sex Differences in Magnetoencephalography-Identified Functional Connectivity in the Human Connectome Project Connectomics of Brain Aging and Dementia Cohort

Publicated to:Brain Connectivity. 12 (6): 561-570 - 2022-01-01 12(6), DOI: 10.1089/brain.2021.0059

Authors: Bruña R; Maestú F; López-Sanz D; Bagic A; Cohen AD; Chang YF; Cheng Y; Doman J; Huppert T; Kim T; Roush RE; Snitz BE; Becker JT

Affiliations

Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina , Universidad Politécnica de Madrid , Universidad Complutense de Madrid - Author
Networking Res Ctr Bioengn Biomat & Nanomed CIBER, Madrid, Spain - Author
Univ Complutense Madrid, Dept Expt Psychol, Madrid, Spain - Author
Univ Complutense Madrid, Dept Psychobiol, Madrid, Spain - Author
Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15261 USA - Author
Univ Pittsburgh, Dept Elect Engn, Pittsburgh, PA USA - Author
Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA - Author
Univ Pittsburgh, Dept Neurosurg, Pittsburgh, PA USA - Author
Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA - Author
Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA - Author
Univ Pittsburgh, Dept Radiol, Pittsburgh, PA 15260 USA - Author
Univ Pittsburgh, Dept Stat, Pittsburgh, PA USA - Author
Univ Politecn Madrid, Ctr Biomed Technol, Lab Cognit & Computat Neurosci UCM UPM, Campus Montegancedo, Madrid 28223, Spain - Author
Universidad Politécnica de Madrid , Universidad Complutense de Madrid - Author
University of Pittsburgh - Author
University of Pittsburgh , University of Pittsburgh Graduate School of Public Health - Author
University of Pittsburgh , University of Pittsburgh School of Medicine - Author
University of Pittsburgh School of Medicine - Author
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Abstract

Introduction: The human brain shows modest traits of sexual dimorphism, with the female brain, on average, 10% smaller than the male brain. These differences do not imply a lowered cognitive performance, but suggest a more optimal brain organization in women. Here we evaluate the patterns of functional connectivity (FC) in women and men from the Connectomics of Brain Aging and Dementia sample. Methods: We used phase locking values to calculate FC from the magnetoencephalography time series in a sample of 138 old adults (87 females and 51 males). We compared the FC patterns between sexes, with the intention of detecting regions with different levels of connectivity. Results: We found a frontal cluster, involving anterior cingulate and the medial frontal lobe, where women showed higher FC values than men. Involved connections included the following: (1) medial parietal areas, such as posterior cingulate cortices and precunei; (2) right insula; and (3) medium cingulate and paracingulate cortices. Moreover, these differences persisted when considering only cognitively intact individuals, but not when considering only cognitively impaired individuals. Discussion: Increased anteroposterior FC has been identified as a biomarker for increased risk of developing cognitive impairment or dementia. In our study, cognitively intact women showed higher levels of FC than their male counterparts. This result suggests that neurodegenerative processes could be taking place in these women, but the changes are undetected by current diagnosis tools. FC, as measured here, might be valuable for early identification of this neurodegeneration.

Keywords

alzheimers-diseasecortical thicknesseegfluid amyloid-betamagnetoencephalographymegmild cognitive impairmentolder-adultsphase-synchronizationsex as a biological variableverbal memoryAdultAgingBrainConnectomeDementiaFemaleFunctional connectivityGender-related differencesHumansMagnetic resonance imagingMagnetoencephalographyMaleSex as a biological variableSex characteristics

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Brain Connectivity due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 136/272, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Neurosciences. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Neuroscience (Miscellaneous).

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-18:

  • Scopus: 2

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-18:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 24.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 27 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 7.
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (BRUÑA FERNANDEZ, RICARDO) .