{rfName}
SM

Indexed in

License and Use

Icono OpenAccess

Altmetrics

Analysis of institutional authors

Dabos LAuthor

Share

September 19, 2022
Publications
>
Article

SME-4-producing Serratia marcescens from Argentina belonging to clade 2 of the S. marcescens phylogeny

Publicated to: Journal Of Antimicrobial Chemotherapy. 74 (7): 1836-1841 - 2019-07-01 74(7), DOI: 10.1093/jac/dkz115

Authors:

Dabos L; Patinõ-Navarrete R; Nastro M; Famiglietti A; Glaser P; Rodriguez CH; Naas T
[+]

Affiliations

Bicetre Hosp, AP HP, Dept Bacteriol Hyg, Le Kremlin Bicetre, France - Author
CNRS, UMR3525, Paris, France - Author
French Natl Reference Ctr Antibiot Resistance, Le Kremlin Bicetre, France - Author
Paris Sud Univ, Fac Med, EA7361 Struct Dynam Funct & Express Broad Spectru, Le Kremlin Bicetre, France - Author
Univ Buenos Aires, Fac Farm & Bioquim, Hosp Clin Jose de San Martin, Dept Bioquim Clin, Buenos Aires, DF, Argentina - Author
Univ Paris Sud, AP HP, Inst Pasteur, Joint Res Unit EERA Evolut & Ecol Resistance Anti, Paris, France - Author
See more

Abstract

Background: SME carbapenemases are increasingly reported, especially from North and South America. Here, we describe an SME-4-producing Serratia marcescens (SME-Sm) clinical isolate from Argentina and compare its genome with other SME-Sm and Sm isolates recovered from public databases. Methods: Sm isolates were characterized by WGS using Illumina technology, susceptibility testing and MIC determination. Carbapenemase activity was revealed by biochemical tests based on imipenem hydrolysis. A whole-genome phylogeny was estimated for all the Sm isolates retrieved from public databases with kSNP3 and a whole-genome phylogenetic analysis based on non-recombinant core SNPs was inferred for Sm complete genomes and for those encoding any blaSME variants. Results: Sm163 was resistant to amoxicillin, temocillin, aztreonam and carbapenems, remaining susceptible to extended-spectrum cephalosporins. WGS analysis of Sm163 revealed a genome of 5139329 bp and a chromosomally encoded blaSME-4 carbapenemase gene located on a genomic island closely related to SmarGI1-1 of Sm N11-02820. Comparison of the Sm genomes revealed that the 14 SME-Sm isolates possess this genomic island inserted at the same loci, that 13/14 belong to clade 1 and that 11/14 form a well-defined subcluster of cluster I of Sm clade 1, while Sm163 belongs to clade 2, suggesting that an SME-encoding genomic island may have been transferred between isolates from different clades. Conclusions: To the best of our knowledge this is the first report of an SME-4-encoding Sm from Argentina. The blaSME-4 gene is located on a SmarGI1-1-like genomic island. The genome of Sm163 belongs to clade 2, unlike all the other SME-Sm isolates, which belong to clade 1.
[+]

Keywords

carbapenemasegeneidentificationisolateRapid detection

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Antimicrobial Chemotherapy due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position 22/271, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmacology & Pharmacy. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-12-21:

  • Google Scholar: 13
  • WoS: 7
  • Scopus: 10
[+]

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-21:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 22.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 28 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
[+]

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Argentina; France.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (DABOS, MARIA LAURA BELEN) .

[+]