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Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Yvert, ThomasAuthorPerez-Ruiz, MargaritaAuthor

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November 28, 2022
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Review

Effectiveness of Physical Exercise Interventions on Pulmonary Function and Physical Fitness in Children and Adults with Cystic Fibrosis: A Systematic Review with Meta-Analysis

Publicated to: Healthcare (Basel). 10 (11): 2205- - 2022-11-01 10(11), DOI: 10.3390/healthcare10112205

Authors:

Garcia-Perez-de-Sevilla, G; Yvert, T; Blanco, A; Pedreschi, AIS; Thuissard, IJ; Perez-Ruiz, M
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Affiliations

Univ Europea Madrid, Fac Biomed Sci, Madrid 28670, Spain - Author
Univ Europea Madrid, Fac Sports Sci, Dept Physiotherapy, Madrid 28670, Spain - Author
Univ Europea Madrid, Fac Sports Sci, Dept Res, Madrid 28670, Spain - Author
Univ Politecn Madrid, Fac Ciencias Actividad Fis & Deporte, Dept Salud & Rendimiento, Inst Nacl Educ Fis INEF, Madrid 28040, Spain - Author
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Abstract

Objective: Physical exercise is associated with several benefits in the treatment of cystic fibrosis (CF), associated with a reduction in patient mortality. The aim of this systematic review was to determine the effectiveness of exercise interventions on physical condition and lung function in children and adults with CF to establish the most appropriate type and dose of physical exercise used so far. Methods: The studies included were randomized controlled trials with physical exercise interventions performed with children or adults with CF, analyzing the effects on pulmonary function, cardiorespiratory capacity, and muscle strength. The variables analyzed in at least four studies in the same population (children or adults) with the same measuring test were included in the meta-analysis. Results: Pulmonary function: There were no changes in the forced expiratory volume 1 s, but mouth expiratory/inspiratory pressures were improved in some studies. Physical fitness: In children, the interventions did not manage to improve the VO2peak (SMD = 0.22; 95%CI: -0.25 to 0.68; p = 0.73) but improved muscle strength. In adults, physical exercise interventions based on high-intensity aerobic training showed positive results in the VO2peak, and in some muscle strength outcomes. Conclusions: Exercise interventions in children and adults with CF are effective in improving muscle strength, cardiovascular capacity, and respiratory muscle function. However, they do not achieve improvements in lung function. The most effective programs are those using strength training or cardiovascular high-intensity interval training, although to date there have been few such interventions.
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Keywords

CapacityCardiorespiratory functionCystic fibrosisDiseaseEnduranceExerciseGood health and well-beingMuscle strengthPhysical fitnessProgramPulmonary functionTolerance

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Healthcare (Basel) due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 43/87, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Health Policy & Services. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Leadership and Management.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.49. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-25, the following number of citations:

  • WoS: 10
  • Scopus: 9
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-25:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 69 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
    • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/87425/

    As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

    • Views: 118
    • Downloads: 64
    Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 3 - Ensure healthy lives and promote well-being for all at all ages, with a probability of 85% according to the mBERT algorithm developed by Aurora University.
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    Leadership analysis of institutional authors

    There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (PEREZ RUIZ, MARGARITA).

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    Project objectives

    El presente estudio persigue los siguientes objetivos: determinar la efectividad de las intervenciones de ejercicio físico sobre la función pulmonar y la condición física en niños y adultos con fibrosis quística; analizar los efectos del ejercicio sobre la capacidad cardiorrespiratoria y la fuerza muscular; establecer el tipo y la dosis más adecuados de ejercicio físico empleados hasta la fecha; evaluar las mejoras en la función muscular respiratoria y la fuerza muscular; y comparar los resultados entre diferentes poblaciones (niños y adultos) y modalidades de entrenamiento, especialmente el entrenamiento aeróbico de alta intensidad y el entrenamiento de fuerza.
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    Most relevant results

    Los resultados más relevantes de la revisión sistemática con metaanálisis sobre intervenciones de ejercicio físico en pacientes con fibrosis quística incluyen: (1) no se observaron cambios significativos en el volumen espiratorio forzado en 1 segundo (FEV1); (2) algunas mejoras en las presiones espiratorias e inspiratorias bucales se reportaron; (3) en niños, no se mejoró el VO2peak (SMD = 0.22; IC95%: -0.25 a 0.68; p = 0.73), aunque sí se incrementó la fuerza muscular; (4) en adultos, los entrenamientos aeróbicos de alta intensidad mejoraron el VO2peak y ciertos indicadores de fuerza muscular; y (5) los programas más efectivos combinan entrenamiento de fuerza o intervalos cardiovasculares de alta intensidad, aunque son escasos en la literatura actual.
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