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The authors thank Luis Revuelta Rueda from Complutense University of Madrid for help with the animal tissue, and Professor Irene Kochevar from Wellman Center of Photomedicine for helpful discussions.Supported by Spanish Government Grant (PRE2018-086169 and FIS2017-84753-R) ; European Research Council (2018-ADG-SILKEYE-833106) ; NIH NEI P30EY 001319; and Unrestricted Funds Research to Prevent Blindness, NY.
Análisis de autorías institucional
Villegas, LupeAutor (correspondencia)Effects of Different Scleral Photo-Crosslinking Modalities on Scleral Stiffness and Hydration
Publicado en:Investigative Ophthalmology & Visual Science. 65 (8): 8- - 2024-08-01 65(8), DOI: 10.1167/iovs.65.8.8
Autores: Villegas, L; Germann, JA; Marcos, S
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Resumen
PURPOSE. The purpose of this study was to evaluate the biomechanical and hydration differences in scleral tissue after two modalities of collagen cross-linking. METHODS. Scleral tissue from 40 adult white rabbit eyes was crosslinked by application of 0.1% Rose Bengal solution followed by 80 J/cm2 green light irradiation (RGX) or by application of 0.1% riboflavin solution followed by 5.4 J/cm2 ultraviolet A irradiation (UVX). Posterior scleral strips were excised from treated and untreated sclera for tensile and hydration-tensile tests. For tensile tests, the strips were subjected to uniaxial extension after excision. For hydration-tensile tests, the strips were dehydrated, rehydrated, and then tested. Young's modulus at 8% strain and swelling rate were estimated. ANOVAs were used to test treated-induced differences in scleral biomechanical and hydration properties. RESULTS. Photo-crosslinked sclera tissue was stiffer (Young's modulus at 8% strain: 10.7 +/- 4.5 MPa, on average across treatments) than untreated scleral tissue (7.1 +/- 4.0 MPa). Scleral stiffness increased 132% after RGX and 90% after UVX compared to untreated sclera. Scleral swelling rate was reduced by 11% after RGX and by 13% after UVX. The stiffness of the treated sclera was also associated with the tissue hydration level. The lower the swelling, the higher the Young's modulus of RGX (-3.8% swelling/MPa) and UVX (-3.5% swelling/MPa) treated sclera. CONCLUSIONS. Cross-linking with RGX and UVX impacted the stiffness and hydration of rabbit posterior sclera. The Rose Bengal with green light irradiation may be an alternative method to determine the efficacy and suitability of inducing scleral tissue stiffening in the treatment of myopia.
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Impacto bibliométrico. Análisis de la aportación y canal de difusión
El trabajo ha sido publicado en la revista Investigative Ophthalmology & Visual Science debido a la progresión y el buen impacto que ha alcanzado en los últimos años, según la agencia WoS (JCR), se ha convertido en una referencia en su campo. En el año de publicación del trabajo, 2024 aún no existen indicios calculados, pero en 2023, se encontraba en la posición 6/95, consiguiendo con ello situarse como revista Q1 (Primer Cuartil), en la categoría Ophthalmology. Destacable, igualmente, el hecho de que la Revista está posicionada por encima del Percentil 90.
2025-07-13:
- Google Scholar: 1
- WoS: 1
- Scopus: 3
Impacto y visibilidad social
Análisis de liderazgo de los autores institucionales
Este trabajo se ha realizado con colaboración internacional, concretamente con investigadores de: United States of America.
Existe un liderazgo significativo ya que algunos de los autores pertenecientes a la institución aparecen como primer o último firmante, se puede apreciar en el detalle: Primer Autor (VILLEGAS LOPEZ, LUPE IVETTE) .
el autor responsable de establecer las labores de correspondencia ha sido VILLEGAS LOPEZ, LUPE IVETTE.