The influence of different urban typologies in the microclimate and the outdoor thermal comfort in the city of Madrid has been evaluated for a summer typical day. Thus, meteorological variables from the Climatic Network of Madrid have been interpolated and assigned to each urban typology. The urban microclimate analysis revels variations of air temperature, relative humidity and wind velocity for each typology; being significative during the night, when it is reached differences of 20C for air temperature and 16% for relative humidity between compacted-high rise and dispersed typologies. Through the urban microclimate data, the thermal comfort is calculated according to the UTCI index. Two representative neighbourhoods of each urban typology are hourly simulated through the SkyHelios-Pro software. Results are assessed through the weighted averages for the selected neighbourhoods' area. They show that during the night there is “no thermal stress”, but variations between the urban categories are found. From 12:00 am to 19:00 pm the thermal sensation is “strong heat stress”, however there are areas for all typologies where a “very strong heat stress” is achieved. Considering the daily UTCI behaviour, Historical Buildings present the worst values. On the other hand, Modern Closed Blocks respond better to the thermal stress.