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The authors declare that financial support was received for the research and/or publication of this article. This work was supported by the Spanish Ministry of Economy and Competitiveness (PID2021-122979OB-C21). Complimentarily, it was supported by predoctoral grants by the Spanish Ministry of Universities (FPU18/00517) to Martin Carrasco-Gomez, (PRE2019-087612) to Alejandra Garcia-Colomo, and (FPU2019/04251) to Jesus Cabrera-& Aacute;lvarez, and by Universidad Complutense de Madrid (CT58/21-CT59/21) to Alberto del Cerro-Leon, which was cofounded by Santander bank. This work was supported by the European Union's Horizon Europe research and innovation programme under Grant Agreement No. 101058516 (eBRAIN-Health).
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Carrasco-Gomez, MartinAutor (correspondencia)Individual alpha frequency tACS reduces static functional connectivity across the default mode network
Publicado en:Frontiers In Human Neuroscience. 19 1534321- - 2025-05-14 19(), DOI: 10.3389/fnhum.2025.1534321
Autores: Carrasco-Gomez, Martin; Garcia-Colomo, Alejandra; Cabrera-Alvarez, Jesus; del Cerro-Leon, Alberto; Gomez-Ariza, Carlos J; Santos, Andres; Maestu, Fernando
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Resumen
Introduction Research on the influence of transcranial alternating current stimulation over alpha functional connectivity (FC) is scarce, even when it poses as a potential treatment for various diseases. This study aimed to investigate the effects of individual alpha frequency tACS (IAF-tACS) on FC within the default mode network (DMN) in healthy individuals, particularly following the triple network model.Materials and methods 27 healthy participants were recruited, who underwent a 20-min IAF-tACS session over parieto-occipital areas and three magnetoencephalography (MEG) recordings: two pre-stimulation and one post-stimulation. Participants were randomly assigned to either the stimulation or sham group. Both dynamic FC (dFC) and static FC (sFC) were evaluated through the leakage corrected amplitude envelope correlation (AEC-c). Statistical analyses compared both Pre-Post FC ratio between groups through ratio t-tests and intragroup FC changes through repeated measures t-tests, with FDR correction applied to account for multiple comparisons. An additional analysis simulated the influence of the cortical folding on the effect of tACS over FC.Results IAF-tACS significantly decreased sFC in intra- and inter-DMN links in the stimulation group compared to the sham group, with a special influence over antero-posterior links between hubs of the DMN. Negative correlations were found between AEC-c sFC changes and power alterations in posterior DMN areas, suggesting a complex interaction between cortical folding and electric field direction. On the other hand, dFC increased in both sham and stimulation groups, and no between-group differences were found.Conclusion Against our initial hypothesis, IAF-tACS reduced sFC in the DMN, possibly due to phase disparities introduced by cortical gyrification. These findings suggest that tACS might modulate FC in a more complex manner than previously thought, highlighting the need for further research into the personalized application of neuromodulation techniques, as well as its potential therapeutic implications for conditions like Alzheimer's disease.
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Impacto bibliométrico. Análisis de la aportación y canal de difusión
El trabajo ha sido publicado en la revista Frontiers In Human Neuroscience debido a la progresión y el buen impacto que ha alcanzado en los últimos años, según la agencia WoS (JCR), se ha convertido en una referencia en su campo. En el año de publicación del trabajo, 2025, se encontraba en la posición 195/310, consiguiendo con ello situarse como revista Q2 (Segundo Cuartil), en la categoría Neurosciences. Destacable, igualmente, el hecho de que la Revista está posicionada en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría .
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Existe un liderazgo significativo ya que algunos de los autores pertenecientes a la institución aparecen como primer o último firmante, se puede apreciar en el detalle: Primer Autor (CARRASCO GOMEZ, MARTIN) .
el autor responsable de establecer las labores de correspondencia ha sido CARRASCO GOMEZ, MARTIN.