{rfName}
Hu

Información del proyecto

ID: 819814

Fecha inicio

01-05-2019

Fecha fin

30-04-2025


Coordinador institucional
Universidad Politécnica de Madrid

Financiación

2 000 000,00 Euros
(Total amount or amount awarded)

Más información en

Análisis de autorías institucional

Treu, SvenjaParticipanteFrank, Darya RivkaParticipanteLozano Soldevilla, DiegoParticipanteKorovaichuk, Maria AlejandraParticipantePeris YagÜe, AlbaParticipanteCosta, ManuelaParticipanteStrange, BryanInvestigador principalCasales Santa, Marta MariaParticipanteHellerstedt, Robin Andreas GunnarParticipanteFetterhoff, Dustin AndrewParticipante

Compartir

16 de marzo de 2021
Proyectos I+D+I y Ayudas
>
Proyecto Competitivo
No

Human Subcortical-Cortical Circuit Dynamics for Remembering the Exceptional

Investigadores/as: FETTERHOFF, DUSTIN ANDREW (Participante); HELLERSTEDT, ROBIN ANDREAS GUNNAR (Participante); CASALES SANTA, MARTA MARIA (Participante); Strange, Bryan (Investigador principal (IP)); Costa, Manuela (Participante); PERIS YAGÜE, ALBA (Participante); KOROVAICHUK, MARIA ALEJANDRA (Participante); Lozano Soldevilla, Diego (Participante); FRANK, DARYA RIVKA (Participante); TREU, SVENJA (Participante)

Afiliaciones

Resumen

Our memory system is optimised for remembering the exceptional over the mundane. We remember better those events that violate predictions generated by the prevailing context, particularly because of surprise or emotional impact. Understanding how we form and retrieve long-term memories for important or salient events is critical for combating the rapidly growing incidence of pathologies associated with memory dysfunction with huge socio-econonomic burden. Human lesion and non-invasive functional imaging data, motivated by findings from animal models, have identified subcortical structures that are critical for upregulating hippocampal function during salient event memory. However, mechanistic understanding of these processes in humans remains scarce, and requires better experimental approaches such as direct intracranial recordings from, and focal electrical stimulation of, these subcortical structures. This project will characterise human subcortico-cortical neuronal circuit dynamics associated with enhanced episodic memory for salient stimuli by studying direct recordings from human hippocampus, amygdala, nucleus accumbens, ventral midbrain and cortex. Within this framework, I will elucidate the electrophysiological mechanisms underlying amygdala-hippocampal-cortical coupling that lead to better memory for emotional stimuli, extend the hippocampal role in detecting unpredicted stimuli to define its role in orchestrating cortical dynamics in unpredictable contexts, and discover the neuronal response profile of the human mesolimbic dopamine system during salient stimulus encoding. The predicted results, based on my own preliminary data, will offer several conceptual breakthroughs, particularly regarding hippocampal function and the role of dopaminergic ventral midbrain in memory. The knowledge gained from this project is a fundamental requirement for designing therapeutic interventions for patients with memory deficits and other neuropsychiatric disorders. (Most relevant results)

Palabras clave

Instituciones participantes

Indicios de calidad

Programa

H2020

Agencias financiadoras

Comisión Europea

Alcance

Internacional no UE

País

Belgium; Spain

Coordinador institucional

Si

Ítems relacionados