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The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Instituto de Salud Carlos III (ISCIII), Ministry of Health, Spain (CPII17/00014; PI18/01188; CP16/00916; and RD16/0012/0014) and cofounded by el Fondo Europeo de Desarrollo Regional (FEDER). Funders had no role in the design, collection, management, analyses, interpretation of the data, preparation, review, approval or decision to submit the manuscript for publication.
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Madrid-Garcia, AAutor o coautorInfluence of colchicine prescription in COVID-19-related hospital admissions: a survival analysis
Publicat a:Therapeutic Advances In Musculoskeletal Disease. 13 - 2021-03-01 13(), DOI: 10.1177/1759720X211002684
Autors: Madrid-Garcia, Alfredo; Perez, Ines; Colomer, Jose Ignacio; Leon-Mateos, Leticia; Jover, Juan A.; Fernandez-Gutierrez, Benjamin; Abasolo-Alcazar, Lydia; Rodriguez-Rodriguez, Luis;
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Aims: To analyze the association between colchicine prescription and COVID-19-related hospital admissions in patients with rheumatic and musculoskeletal diseases (RMDs). Methods: Patients attending a rheumatology outpatient clinic from a tertiary care center in Madrid, Spain, from 1 September 2019 to 29 February 2020 were included. Patients were assigned as exposed or unexposed based on whether they were prescribed with colchicine in their last visit to the clinic during the 6 months before the start of the observation period. Treatment changes during the observation period were also considered. The primary outcome was COVID-19-related hospital admissions between 1 March and 20 May 2020. Secondary outcome included COVID-19-related mortality. Several weighting techniques for data balancing, based and non-based on the propensity score, followed by Cox regressions were performed to estimate the association of colchicine prescription on both outcomes. Discussion: The number of patients entered in the study was 9379, with 406 and 9002 exposed and unexposed follow-up periods, respectively. Generalized Boosted Models (GBMs) and Empirical Balancing Calibration Weighting (EBCW) methods showed the best balance for COVID-19-related hospital admissions. Colchicine prescription did not show a statistically significant association after covariable balancing (p-value = 0.195 and 0.059 for GBM and EBCW, respectively). Regarding mortality, the low number of events prevented a success variable balancing and analysis. Conclusion: Colchicine prescription does not play a significant protective or risk role in RMD patients regarding COVID-19-related hospital admissions. Our observations could support the maintenance of colchicine prescription in those patients already being treated, as it is not associated with a worse prognosis.
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Impacte bibliomètric. Anàlisi de la contribució i canal de difusió
El treball ha estat publicat a la revista Therapeutic Advances In Musculoskeletal Disease a causa de la seva progressió i el bon impacte que ha aconseguit en els últims anys, segons l'agència Scopus (SJR), s'ha convertit en una referència en el seu camp. A l'any de publicació del treball, 2021, es trobava a la posició , aconseguint així situar-se com a revista Q2 (Segundo Cuartil), en la categoria Orthopedics and Sports Medicine. Destacable, igualment, el fet que la revista està posicionada en el Cuartil Q3 per a l'agència WoS (JCR) en la categoria Rheumatology.
Des d'una perspectiva relativa, i atenent a l'indicador de impacte normalitzat calculat a partir del Field Citation Ratio (FCR) de la font Dimensions, proporciona un valor de: 2.94, el que indica que, comparat amb treballs en la mateixa disciplina i en el mateix any de publicació, el situa com un treball citat per sobre de la mitjana. (font consultada: Dimensions Jul 2025)
Concretament, i atenent a les diferents agències d'indexació, aquest treball ha acumulat, fins a la data 2025-07-16, el següent nombre de cites:
- WoS: 5
- Google Scholar: 8
Impacte i visibilitat social
Anàlisi del lideratge dels autors institucionals
Hi ha un lideratge significatiu, ja que alguns dels autors pertanyents a la institució apareixen com a primer o últim signant, es pot apreciar en el detall: Primer Autor (MADRID GARCIA, ALFREDO) .