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Analysis of institutional authors

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November 21, 2023
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Six-Month Periodic Fasting in Patients With Type 2 Diabetes and Diabetic Nephropathy: A Proof-of-Concept Study

Publicated to: Journal Of Clinical Endocrinology & Metabolism. 107 (8): 2167-2181 - 2022-01-01 107(8), DOI: 10.1210/clinem/dgac197

Authors:

Sulaj A; Kopf S; von Rauchhaupt E; Kliemank E; Brune M; Kender Z; Bartl H; Cortizo FG; Klepac K; Han Z; Kumar V; Longo V; Teleman A; Okun JG; Morgenstern J; Fleming T; Szendroedi J; Herzig S; Nawroth PP
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Affiliations

Chair Molecular Metabolic Control, Technical University Munich, Munich, Germany - Author
Department of Endocrinology Diabetology Metabolism and Clinical Chemistry (Internal Medicine 1), Heidelberg University Hospital, Heidelberg, Germany - Author
Department of General Pediatrics, Division of Neuropediatrics and Metabolic Medicine, Centre for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany - Author
FIRC Institute of Molecular Oncology, Italian Foundation for Cancer Research Institute of Molecular Oncology, Milan, Italy - Author
German Cancer Research Center (DKFZ), Division of Signal Transduction in Cancer and Metabolism, Heidelberg, Germany - Author
German Center of Diabetes Research (DZD), Neuherberg, Germany - Author
Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany - Author
Joint Heidelberg-IDC Translational Diabetes Program, Helmholtz Center Munich, Neuherberg, Germany - Author
Joint Heidelberg-IDC Translational Diabetes Program, Internal Medicine 1, Heidelberg University Hospital, Heidelberg, Germany - Author
Longevity Institute, School of Gerontology, Department of Biological Sciences, University of Southern California, Los Angeles, CA, United States - Author
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Abstract

Context: Novel fasting interventions have gained scientific and public attention. Periodic fasting has emerged as a dietary modification promoting beneficial effects on metabolic syndrome. Objective: Assess whether periodic fasting reduces albuminuria and activates nephropathy-driven pathways. Design/Participants: Proof-of-concept study where individuals with type 2 diabetes (n = 40) and increased albumin-to-creatinine ratio (ACR) were randomly assigned to receive a monthly fasting-mimicking diet (FMD) or a Mediterranean diet for 6 months with 3-month follow-up. Main Outcomes Measures: Change in ACR was assessed by analysis of covariance adjusted for age, sex, weight loss, and baseline value. Prespecified subgroup analysis for patients with micro- vs macroalbuminuria at baseline was performed. Change in homeostatic model assessment for insulin resistance (HOMA-IR), circulating markers of dicarbonyl detoxification (methylglyoxal-derived hydroimidazolone 1, glyoxalase-1, and hydroxyacetone), DNA-damage/repair (phosphorylated histone H2AX), lipid oxidation (acylcarnitines), and senescence (soluble urokinase plasminogen activator receptor) were assessed as exploratory endpoints. Results: FMD was well tolerated with 71% to 95% of the participants reporting no adverse effects. After 6 months, change in ACR was comparable between study groups [110.3 (99.2, 121.5) mg/g; P = 0.45]. FMD led to a reduction of ACR in patients with microalbuminuria levels at baseline [-30.3 (-35.7, -24.9) mg/g; P ≤ 0.05] but not in those with macroalbuminuria [434.0 (404.7, 463.4) mg/g; P = 0.23]. FMD reduced HOMA-IR [-3.8 (-5.6, -2.0); P ≤ 0.05] and soluble urokinase plasminogen activator receptor [-156.6 (-172.9, -140.4) pg/mL; P ≤ 0.05], while no change was observed in markers of dicarbonyl detoxification or DNA-damage/repair. Change in acylcarnitines was related to patient responsiveness to ACR improvement. At follow-up only HOMA-IR reduction [-1.9 (-3.7, -0.1), P ≤ 0.05]) was sustained. Conclusions: Improvement of microalbuminuria and of markers of insulin resistance, lipid oxidation, and senescence suggest the potential beneficial effects of periodic fasting in type 2 diabetes. © The Author(s) 2022.
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Keywords

AcylcarnitineAdultAgedAgingAlbumin to creatinine ratioAlbuminuriaArticleBody weight lossClinical articleComparative studyControlled studyDetoxificationDiabetic nephropathyDicarbonyl detoxificationDiet restrictionDna repairFastingFasting mimicking dietFemaleFollow upHistone h2axHomeostasis model assessmentHumanHuman cellHydroxyacetoneInsulin resistanceLactoylglutathione lyaseLipid oxidationMacroalbuminuriaMaleMediterranean dietMethylglyoxalMethylglyoxal derived hydroimidazolone 1MicroalbuminuriaMiddle agedNon insulin dependent diabetes mellitusPeriodic fastingProof of conceptProtein analysisProtein phosphorylationRandomized controlled trialSenescenceSex ratioUnclassified drugUrokinase receptor

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Clinical Endocrinology & Metabolism due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 31/145, thus managing to position itself as a Q1 (Primer Cuartil), in the category Endocrinology & Metabolism.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations from Scopus Elsevier, it yields a value for the Field-Weighted Citation Impact from the Scopus agency: 2.16, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-12-21, the following number of citations:

  • Scopus: 27
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-21:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 93.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 94 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 573.
  • The number of mentions on the social network X (formerly Twitter): 72 (Altmetric).
  • The number of mentions in news outlets: 73 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Germany; Italy; United States of America.

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