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Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Pantoja Arevalo, Lisset ShyrlenneCorresponding AuthorGesteiro E.AuthorGonzález-Gross M.Author

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January 8, 2024
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Article

Association between Food-Specific Immunoglobulin G4 Antibodies in Adults with Self-Reported Signs and Symptoms Attributed to Adverse Reactions to Foodstuffs

Publicated to: Biomedicines. 11 (12): 3335- - 2023-12-01 11(12), DOI: 10.3390/biomedicines11123335

Authors:

Pantoja-Arevalo, Lisset; Gesteiro, Eva; Matthias, Torsten; Urrialde, Rafael; Gonzalez-Gross, Marcela
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Affiliations

Aesku Diagnost GmbH, Dept Res & Dev, D-55234 Wendelsheim, Germany - Author
Biomedical Research Centre of Pathophysiology, Obesity and Nutrition-CIBERobn, Carlos III Health Institute, Madrid, 28040, Spain - Author
Carlos III Hlth Inst, Biomed Res Ctr Pathophysiol Obes & Nutr CIBERobn, Madrid 28040, Spain - Author
Department of Genetics, Physiology and Microbiology, Universidad Complutense de Madrid, Madrid, 28040, Spain - Author
Department of Pharmaceutical and Health Sciences, Universidad San Pablo CEU, Madrid, 28040, Spain - Author
Department of Research and Development, Aesku.Diagnostics GmbH, Wendelsheim, 55234, Germany - Author
EXERNET Spanish Research Network on Physical Exercise and Health, Universidad de Zaragoza, Zaragoza, 50009, Spain - Author
Grupo de Investigación en nutrición, ejercicio y estilo de vida saludable. ImFINE. Universidad Politécnica de Madrid - Author
Univ Complutense Madrid, Dept Genet Physiol & Microbiol, Madrid 28040, Spain - Author
Univ Politecn Madrid, Dept Hlth & Human Performance, ImFINE Res Grp, Madrid 28040, Spain - Author
Univ San Pablo CEU, Dept Pharmaceut & Hlth Sci, Madrid 28040, Spain - Author
Univ Zaragoza, EXERNET Spanish Res Network Phys Exercise & Hlth, Zaragoza 50009, Spain - Author
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Abstract

Signs and symptoms attributed to adverse reactions to foodstuffs (ARFS) need tools for research and evaluation in clinical practice. The objectives of this study were (a) to evaluate the most frequent self-reported signs and symptoms attributed to ARFS in Spanish adults, (b) to determine the prevalence of food-specific IgG4 antibody reactions (AbRs), and (c) to investigate the association between self-reported ARFS symptomatology and food-specific IgG4 AbRs. Food-specific IgG4 AbRs against 57 common food and beverages (AESKUCARE-T2FA® in vitro point-of-care test kit, Aesku.Diagnostics GmbH, Germany) were determined in capillary blood samples of 205 volunteers living in the Region of Madrid (Spain). The most frequent self-reported signs and symptoms were related to skin (43%), digestive (41%), and nervous system (NS, 33%) problems. The prevalence of food-specific IgG4 AbRs was cow’s milk (73%), sheep’s milk (70%), casein (66%), and goat’s milk (56.10%). Positive IgG4 AbRs against tomato had a profile consisting of 3/4 of skin problems, more than half of digestive, and 2/5 of NS self-reported signs and symptoms. In conclusion, at least 1/3 of the studied sample reported skin, digestive, and NS signs and symptoms. The most frequent food-specific IgG4 AbRs were related to dairy. Skin problems were more frequent in positive tomato IgG4 AbRs.
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Keywords

allergensallergyantibodiesdiagnosisfood hypersensitivityigg antibodiesimmunoglobulin ginflammationintolerancepoint-of-care testingsigns and symptomsAdverse effectsAllergensAntibodiesFood hypersensitivityImmunoglobulin gIrritable-bowel-syndromePoint-of-care testingSigns and symptomsZero hunger

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Biomedicines due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 85/354, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmacology & Pharmacy.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-27:

  • Google Scholar: 3
  • WoS: 2
  • Scopus: 2
  • Europe PMC: 3
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-27:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 8.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 8 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 6.
  • The number of mentions on the social network X (formerly Twitter): 8 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/84811/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 130
  • Downloads: 67
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 2 - End hunger, achieve food security and improved nutrition and promote sustainable agriculture, with a probability of 65% according to the mBERT algorithm developed by Aurora University.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Germany.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (PANTOJA AREVALO, LISSET SHYRLENNE) and Last Author (GONZALEZ GROSS, MARIA MARCELA).

the author responsible for correspondence tasks has been PANTOJA AREVALO, LISSET SHYRLENNE.

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Observations

Afiliación principal (Pantoja-Arévalo L et al): Grupo de Investigación ImFINE. Departamento de Salud y Rendimiento Humano. Universidad Politécnica de Madrid. 28040 Madrid
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Project objectives

Los objetivos perseguidos en esta aportación fueron: evaluar las manifestaciones clínicas más frecuentes autoinformadas atribuidas a reacciones adversas a alimentos en adultos españoles; determinar la prevalencia de anticuerpos IgG4 específicos frente a alimentos comunes; investigar la asociación entre la sintomatología autoinformada y la presencia de anticuerpos IgG4 específicos; caracterizar el perfil de reacciones IgG4 frente a alimentos específicos como la leche de vaca, oveja, cabra y el tomate; y analizar la distribución de signos y síntomas relacionados con problemas cutáneos, digestivos y del sistema nervioso en la muestra estudiada.
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Most relevant results

El estudio evaluó la asociación entre signos y síntomas autoinformados atribuidos a reacciones adversas a alimentos (ARFS) y la presencia de anticuerpos IgG4 específicos en adultos españoles. Los resultados más relevantes incluyen: 1) el 43% de los participantes reportó problemas cutáneos, el 41% síntomas digestivos y el 33% afectación del sistema nervioso; 2) la prevalencia de anticuerpos IgG4 específicos fue mayor para leche de vaca (73%), leche de oveja (70%), caseína (66%) y leche de cabra (56,10%); 3) la presencia de IgG4 positiva frente al tomate se asoció con un perfil de síntomas donde el 75% correspondió a problemas cutáneos, más de la mitad a síntomas digestivos y el 40% a signos neurológicos.
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Awards linked to the item

Afiliación principal (primer autor Lisset Shyrlenne Pantoja Arevalo, Pantoja-Arevalo L., Pantoja-Arévalo L.): ESPAÑOL: Grupo de Investigación ImFINE, Departamento de Salud y Rendimiento Humano, Universidad Politécnica de Madrid, 28040 Madrid, España. INGLÉS: ImFINE Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, 28040 Madrid, Spain. REVISTA BIOMEDICINES DE MDPI : Q1
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