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Analysis of institutional authors

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June 3, 2024
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Activation of autophagy by metals in Chlamydomonas reinhardtii

Publicated to:Eukaryotic Cell. 14 (9): 964-973 - 2015-01-01 14(9), DOI: 10.1128/EC.00081-15

Authors: Pérez-Martín M; Blaby-Haas CE; Pérez-Pérez ME; Andrés-Garrido A; Blaby IK; Merchant SS; Crespo JL

Affiliations

Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, United States - Author
Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, United States, Institute for Genomics and Proteomics, University of California, Los Angeles, CA, United States - Author
Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Sevilla, Seville, Spain - Author
M.; Instituto de Bioquímica Vegetal y Fotosíntesis; Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Sevilla; Seville; Spain - Author

Abstract

Autophagy is an intracellular self-degradation pathway by which eukaryotic cells recycle their own material in response to specific stress conditions. Exposure to high concentrations of metals causes cell damage, although the effect of metal stress on autophagy has not been explored in photosynthetic organisms. In this study, we investigated the effect of metal excess on autophagy in the model unicellular green alga Chlamydomonas reinhardtii. We show in cells treated with nickel an upregulation of ATG8 that is independent of CRR1, a global regulator of copper signaling in Chlamydomonas. A similar effect on ATG8 was observed with copper and cobalt but not with cadmium or mercury ions. Transcriptome sequencing data revealed an increase in the abundance of the protein degradation machinery, including that responsible for autophagy, and a substantial overlap of that increased abundance with the hydrogen peroxide response in cells treated with nickel ions. Thus, our results indicate that metal stress triggers autophagy in Chlamydomonas and suggest that excess nickel may cause oxidative damage, which in turn activates degradative pathways, including autophagy, to clear impaired components and recover cellular homeostasis. © 2015, American Society for Microbiology. All Rights Reserved.

Keywords

AutophagyCation transport proteinCation transport proteinsChlamydomonas reinhardtiiDrug effectsGeneticsHeavy metalMetabolismMetals, heavyOxidative stressPlant proteinPlant proteinsTranscriptome

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Eukaryotic Cell due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2015, it was in position 6/29, thus managing to position itself as a Q1 (Primer Cuartil), in the category Mycology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.46, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-12, the following number of citations:

  • Scopus: 29

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-12:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 78.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 78 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.5.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (PÉREZ MARTÍN, MARTA) .