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Analysis of institutional authors

Arrieta, Marina PAuthor

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September 8, 2024
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Experimental and theoretical characterization of the release kinetic of carvacrol as inclusion complexes with β-cyclodextrin in poly(lactic acid) and Mater-Bi® ® processed by supercritical impregnation

Publicated to: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 278 - 2024-10-01 278(), DOI: 10.1016/j.ijbiomac.2024.133946

Authors:

Rivera, P; Torres, A; Romero, J; Rodríguez, F; Arrieta, MP; Olea, F; Silva, T; Maldonado, P; Quijada-Maldonado, E; Tapia, A
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Affiliations

Grp Invest Polimeros Caracterizac & Aplicac POLCA, Madrid 28006, Spain - Author
Univ Politecn Madrid, Escuela Tecn Super Ingn Ind, Dept Ingn Quim Ind & Medio Ambiente, ETSII UPM, Calle Jose Gutierrez Abascal 2, Madrid 28006, Spain - Author
Univ Santiago Chile USACH, Dept Chem Engn & Bioproc, Lab Separat Proc Intensificat SPI, Santiago, Chile - Author
Univ Santiago Chile USACH, Fac Technol, Packaging Innovat Ctr LABEN, Dept Food Sci & Technol,Ctr Dev Nanosci & Nanotech, Santiago 9170201, Chile - Author
Univ Santiago Chile, Engn Fac, Dept Chem Engn & Bioproc, Lab Membrane Separat Proc LabProSeM, Santiago, Chile - Author
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Abstract

The incorporation of active compounds into polymeric matrices using traditional methods has several drawbacks mainly due to the high volatility and thermal sensitivity of these substances. A solution to this problem could be the incorporation of bioactive compounds forming inclusion complexes as a strategy to improve the chemical stability, bioactivity and achieve controlled release. In this work, beta-cyclodextrin/carvacrol inclusion complex was prepared by spray drying to be incorporated into poly(lactic acid) (PLA) and Mater-Bi (R) films by supercritical CO2 impregnation. The impregnation process was carried out at pressures of 10, 15 and 20 MPa and at 40 degrees C. Both polymers showed the highest amount of incorporated inclusion complex at 15 MPa, where the percentage of impregnation varied from 0.6 % to 7.1 % in Mater-Bi (R) and PLA, respectively. Release tests for PLA films impregnated with inclusion complex showed a slow release of the active compound, which did not reach equilibrium after 350 h under the experimental conditions. This prolonged release was not observed in Mater-Bi (R) due to the lower incorporation of the inclusion complex. The release rate was described herein by a comprehensive phenomenological model considering the decomplexation kinetics combined with the equilibrium and mass transfer expressions.
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Keywords

Active compoundsAntifungalAntioxidant activityArticleBeta cyclodextrinBeta cyclodextrin derivativeBeta-cyclodextrinBeta-cyclodextrinsCarvacrolChemistryCinnamaldehydeCo2 impregnationControlled studyCymeneCymenesDifferential scanning calorimetryDisintegrationDrug liberationDrug releaseEquilibrium constantFiberFilmsFourier transform infrared spectroscopyHigh performance liquid chromatographyHigh volatilityInclusion complexKinetic releaseKineticsKinetics releaseMass transfeMass transferMater-biMathematical modelNonhumanPoly lactic acidPolyesterPolyestersPolylactic acidPolylactidePolymeric matricesQuantum chemistryRelease kineticsScanning electron microscopySpray dryingSupercritical impregnationThermal-stabilityThermodynamicsThermogravimetryThermostabilityThymolΒ-cyclodextrin

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 6/94, thus managing to position itself as a Q1 (Primer Cuartil), in the category Polymer Science. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-24:

  • WoS: 4
  • Scopus: 4
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-24:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 20 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/92099/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 42
  • Downloads: 54
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Chile; United States of America.

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Awards linked to the item

This research was supported by the projects ANID FONDECYT N degrees 1221219 and N degrees 1230795. The authors also acknowledge the support of the National Agency for Research and Development (ANID-Chile) through the Doctoral Scholarship [Doctorado Nacional/2022-21221075] .The University of Santiago de Chile supported this work through the Doctoral Scholarship Framework Agreement (2020-2021) , DICYT Project 092311RF_Ayudante and Project AFB 220001 Center for the Development of Nanoscience and Nanotechnology (CEDENNA) .This research has also been funded by the Spanish Ministry of Science and Innovation (MICINN) through the PID-AEI project (grant PID2021-123753NA-C32) funded by MCIN/AEI/10.13039/501100011033 and by ERDF "A way of making Europe" by the "European Union".
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