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Health Foundation "Novel methods to explore the value of cognitive health in a place" (award reference number FR-000002341). PN is funded by the Wellcome Trust. NIHR Senior Investigators. Dementias Platform UK. The author thanks Yoav Ben-Shlomo for valuable comments on the draft manuscript.
Analysis of institutional authors
Pinilla, Marta SuarezAuthorThe Cognitive Footprint of Medication Use
Publicated to:Brain And Behavior. 15 (1): e70200- - 2025-01-01 15(1), DOI: 10.1002/brb3.70200
Authors: Pinilla, MS; Stoner, CR; Knapp, M; Nachev, P; Rossor, M
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Abstract
IntroductionThe cognitive side-effects of medication are common, but often overlooked in practice, and not routinely considered in interventional trials or post-market surveillance. The cognitive footprint of a medication seeks to quantify the impact of its cognitive effects based on magnitude, duration, and interaction with other factors, evaluated across the exposed population.MethodsBayesian multivariable regression analysis of retrospective population-based cross-sectional cohorts.ResultsWe replicate positive and negative cognitive effects of commonly used medications in UK Biobank, and extend observed associations to two additional cohorts, the EPIC Norfolk, and the Caerphilly Prospective Cohort. We quantify the resultant cumulative impact at the population level given known patterns of prescribing and compare it with exemplar common diseases.ConclusionThe cognitive side-effects of commonly used drugs may have significant impact at the population level. Consideration should be given to a routine structured assessment of cognition in interventional trials and post-market surveillance.
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Quality index
Bibliometric impact. Analysis of the contribution and dissemination channel
The work has been published in the journal Brain And Behavior due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 176/310, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Neurosciences. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Behavioral Neuroscience.
Impact and social visibility
Leadership analysis of institutional authors
This work has been carried out with international collaboration, specifically with researchers from: United Kingdom.
There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (SUAREZ PINILLA, MARTA) .