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Article has an altmetric score of 83

Grant support

Health Foundation "Novel methods to explore the value of cognitive health in a place" (award reference number FR-000002341). PN is funded by the Wellcome Trust. NIHR Senior Investigators. Dementias Platform UK. The author thanks Yoav Ben-Shlomo for valuable comments on the draft manuscript.

Analysis of institutional authors

Pinilla, Marta SuarezAuthor

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January 26, 2025
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The Cognitive Footprint of Medication Use

Publicated to:Brain And Behavior. 15 (1): e70200- - 2025-01-01 15(1), DOI: 10.1002/brb3.70200

Authors: Pinilla, MS; Stoner, CR; Knapp, M; Nachev, P; Rossor, M

Affiliations

London Sch Econ & Polit Sci, Hlth Policy Dept, London, England - Author
UCL, UCL Queen Sq Inst Neurol, London, England - Author
Univ Greenwich, Ctr Chron Illness & Ageing, Sch Human Sci, Pk Row, London, England - Author
Univ Politecn Madrid, Ctr Biomed Technol, Clin Neurosci Lab, Madrid, Spain - Author

Abstract

IntroductionThe cognitive side-effects of medication are common, but often overlooked in practice, and not routinely considered in interventional trials or post-market surveillance. The cognitive footprint of a medication seeks to quantify the impact of its cognitive effects based on magnitude, duration, and interaction with other factors, evaluated across the exposed population.MethodsBayesian multivariable regression analysis of retrospective population-based cross-sectional cohorts.ResultsWe replicate positive and negative cognitive effects of commonly used medications in UK Biobank, and extend observed associations to two additional cohorts, the EPIC Norfolk, and the Caerphilly Prospective Cohort. We quantify the resultant cumulative impact at the population level given known patterns of prescribing and compare it with exemplar common diseases.ConclusionThe cognitive side-effects of commonly used drugs may have significant impact at the population level. Consideration should be given to a routine structured assessment of cognition in interventional trials and post-market surveillance.

Keywords

BrainCognitionCognitive footprintDementiLarge-scale cohortsMedication side effectsMedicationsRiskSocioeconomic-status

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Brain And Behavior due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 174/314, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Neurosciences. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Behavioral Neuroscience.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-25:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 13.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 14 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 82.5.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).
  • The number of mentions in news outlets: 9 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United Kingdom.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (SUAREZ PINILLA, MARTA) .