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Analysis of institutional authors

Domínguez-álvaro M.Authorálvarez De Andrés E.Author

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February 5, 2025
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Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry

Publicated to: Arthritis Research & Therapy. 27 (1): - 2025-01-01 27(1), DOI: 10.1186/s13075-024-03468-6

Authors:

Molina-Collada J; Domínguez-Álvaro M; Melero-González RB; de Miguel E; Silva-Díaz M; Valero Jaimes JA; González I; Sánchez Martín J; Narváez J; Calvet J; Casafont-Solé I; Román Ivorra JA; Labrada Arrabal S; Vasques Rocha M; Iñiguez CL; Bustabad Reyes MS; Campos Fernández C; Alcalde Villar M; Mas AJ; Blanco R; Silva Fernández L; Egues Dubuc CA; López Domínguez L; Belzunegui JM; Lluch J; Calvo Zorrilla I; Galíndez Agirregoikoa E; Huaylla A; Riesco Bárcena C; Ortiz Sanjuán F; Muñoz Jimenez A; Aguilera Cros C; Ruíz Roman A; Garrido N; Palomeque Vargas A; Serrano Warleta M; Morán Álvarez P; Tortosa Cabañas M; Larena Grijalba C; García Villanueva MJ; Lencastre Da Veiga CG; González-Gay MÁ; Sánchez-Andrade Fernández A; Miranda Filloy JA; Vázquez Rodríguez TR; Álvarez Rivas N; García Porrúa C; Vicente Rabaneda EF; Valero Martínez C; Uriarte-Ecenarro M; Castañeda Sanz S; Monjo-Henry I; Fernandez-Fernandez E; Calvo Allen J; Hernández Hernández V; García Dorta A; García González M; Cacheda AP; Toniolo E; Ibáñez Barcelo M; Ros Vilamajó I; Álvarez de Andrés E; Macia Villa C; Rodríguez Cambrón AB; Cabero del Pozo F; Cruz Valenciano AF; Milena Millán A; Magallares B; Castellví I; Corominas H; Moya Alvarado P; Navarro Angeles VA; Estrada Alarcón PV; Guzman J; Altabás I; Pego JM; Barbazán C; Pérez N; Maceiras F; Hernández Rodríguez I; Calvo Catalá J; Rueda Cid A; Molina Almela C; Camins J; Holgado Pérez S; Riveros Frutos A; Salman Monte T; Lois Bermejo PM; Font Urgelles J; Rodríguez Rodríguez L; Léon Mateos L; Abasolo Alcázar L; Almorza T; Carreira P; Loza Cortina E; Restrepo Vélez J; Gutiérrez Polo R; Garrido Courel L; Paniagua Zudaire I; Horcada Rubio L; del Val del Amo N; Fito Manteca MC; Mendizábal Mateos J; Aldasoro Cáceres V; Pérez Sandoval T; Díez Álvarez E; Moriano Morales C
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Affiliations

Department of Rheumatology; Hospital General Universitario Gregorio Marañón; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM); Madrid; Spain - Author
Research Unit; Sociedad Española de Reumatología; Madrid; Spain - Author
Rheumatology Department; Complejo Hospitalario Universitario de A Coruña; La Coruña; Spain - Author
Rheumatology Department; Complexo Hospitalario Universitario de Ourense; Ourense; Spain - Author
Rheumatology Department; Hospital del Mar; Barcelona; Spain - Author
Rheumatology Department; Hospital Universitari Bellvitge. Hospitalet de Llobregat; Barcelona; Spain - Author
Rheumatology Department; Hospital Universitari Germans Trias i Pujol; Badalona; Barcelona; Spain - Author
Rheumatology Department; Hospital Universitari i Politècnic La Fe; Valencia; Spain - Author
Rheumatology Department; Hospital Universitari Son Llàtzer; Palma de Mallorca; Spain - Author
Rheumatology Department; Hospital Universitario Araba; Vitoria-Gasteiz; Spain - Author
Rheumatology Department; Hospital Universitario de Canarias; La Laguna; Canarias; Spain - Author
Rheumatology Department; Hospital Universitario de León; León; Spain - Author
Rheumatology Department; Hospital Universitario Donosti; Donostia; Spain - Author
Rheumatology Department; Hospital Universitario La Paz; Madrid; Spain - Author
Rheumatology Department; Hospital Universitario Marqués de Valdecilla. IDIVAL Immunopathology group; Santander; Spain - Author
Rheumatology Department; Hospital Universitario Severo Ochoa Leganés; Madrid; Spain - Author
Rheumatology Department; Parc Taulí Hospital Universitari. Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA) (UAB); Sabadell; Spain - Author
Rheumatology; Consorci Hospital General Universitari de València; Comunitat Valenciana; Spain - Author
Rheumatology; Hospital Universitario Lucus Augusti; Galicia; Spain - Author
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Abstract

Objectives: To compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality. Methods: ARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, clinical, imaging, histological and mortality data were collected retrospectively. Only patients with at least one year of follow-up were included for analysis. The mortality rates were expressed as the number of deaths per 1000 person-years, with 95% confidence interval (CI) by sex and age group. Kaplan-Meier method was performed for survival analysis. The factors influencing mortality were analyzed using Cox regression model. Results: A total of 1200 patients with GCA were analyzed, with a mean (SD) follow-up of 2.18 (1.53) years. The overall five-year cumulative mortality rate (95%CI) was 37.86 (31.75-43.96) per 1000 patients/year. The cumulative mortality rate was significantly higher in males than females (59.04vs29.06; p<0.001). The age- and sex-adjusted cumulative mortality rate was similar to the Spanish general population (19.75vs20.72;p=0.559). In the multivariate analysis, older age (HR 1.11, 95%CI 1.073-1.142) and male sex (HR 1.775, 95%CI 1.214-2.594) were associated with increased mortality. Headache (HR 0.55, 95%CI 0.362-0.843) and high hemoglobin levels (HR 0.85, 95%CI 0.744-0.970) were protective factors against death. Conclusions: The overall five-year age- and sex-adjusted cumulative mortality rate in GCA is similar compared to the general population. Older age and male sex appear to be associated with an increased risk of mortality, whereas headache and high hemoglobin levels might serve as protective factors against death. © The Author(s) 2025.
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Keywords

AgeAgedAged, 80 and overAntithrombocytic agentArticleBisphosphonic acid derivativeC reactive proteinCalciumClinical featureClinical trialComputer assisted tomographyDemographyDisease associationDisease registryEchographyEpidemiologyErythrocyte sedimentation rateFemaleFollow upGiant cell arteritisGlucocorticoidHeadacheHemoglobinHemoglobin blood levelHistopathologyHumanHumansKaplan meier methodLeflunomideMajor clinical studyMaleMedical societyMethotrexateMiddle agedMortalityMortality rateMortality riskMulticenter studyNuclear magnetic resonance imagingPlatelet countPositron emission tomography-computed tomographyPrednisoneProportional hazards modelRegisterRegistriesRetrospective studiesRetrospective studySex differenceSpainSurvivalSurvival analysisVasculitisVery elderlyVitamin d

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Arthritis Research & Therapy due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 8/58, thus managing to position itself as a Q1 (Primer Cuartil), in the category Rheumatology.

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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-20:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 3.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 3 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 27.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 19 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Mali; United States of America.

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