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Analysis of institutional authors

Luque-Agudo, VAuthor

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February 28, 2025
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Antiproliferative activity of new 2-glyco-3-nitro1,2-dihydroquinolines and quinolines synthesized under solventless conditions promoted by neutral alumina

Publicated to: New Journal Of Chemistry. 42 (22): 18342-18347 - 2018-11-21 42(22), DOI: 10.1039/c8nj03372b

Authors:

Luque-Agudo, V; Padron, Jose M; Roman, E; Serrano, J A; Gil, M V
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Affiliations

Univ Extremadura, Fac Ciencias, Dept Quim Organ & Inorgan, IACYS Unidad Quim Verde & Desarrollo Sostenible, Badajoz 06006, Spain - Author
Univ La Laguna, Ctr Invest Biomed Canarias CIBICAN, BioLab Inst Univ Bioorgan Antonio Gonzalez IUBO A, E-38206 Tenerife, Spain - Author

Abstract

This paper describes the syntheses of new 2-glyco-3-nitro-1,2-dihydroquinolines and 2-glyco-3-nitroquinolines by one-pot aza-Michael-Henry-dehydration reactions using a minimal amount of solvent and neutral alumina as the heterogeneous catalyst. The reactivity of the nitro group-double bond system has also been investigated; thus, the addition of indole or pyrrole to N-formylated 1,2-dihydroquinolines has been studied. Finally, the cytotoxicity and antiproliferative activity of these new compounds have been evaluated against a panel of six human solid tumor cell lines and compared to pharmacological reference compounds, finding that their activity is in the low micromolar range and that the carbohydrate moiety configuration modulates the GI(50) values.
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Keywords

2 glyco 3 nitro 1,2 dihydroquinoline derivative2-dihydroquinolines3-nitro-1A-549 cell lineAcidAluminum oxideAntibacterialAntiproliferative activityArticleCarbohydrate analysisCatalystCatalyzed synthesisChiralityCisplatinConjugate additionControlled studyCryptolepinCytotoxic agentDiastereoisomerDihydroquinoline derivativeDrug cytotoxicityDrug synthesisEfficient synthesisEtoposideFemaleFluorouracilHbl-100 cell lineHela cell lineHumanHuman cellIdentificationLung non-small cell carcinoma cell lineNucleophilicityOrganocatalytic asymmetric-synthesisPlant alkaloidsPriority journalQuantitative structure activity relationQuinoline derivativeReaction timeStereochemistryStereospecificityT-47d cell lineUnclassified drugWidr cell line

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal New Journal Of Chemistry due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2018, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Materials Chemistry.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-01-20:

  • Open Alex: 4
  • WoS: 4
  • Scopus: 4
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-01-20:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 4 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (LUQUE AGUDO, VERONICA) .

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Awards linked to the item

This work was supported by the Gobierno deGobierno de Extremadura-Ayuda a Grupos de Investigacion Catalogados and Fondo Europeo de Desarrollo Regional (Grant GR15022). We also thank the Universidad de Extremadura, Plan de Iniciacion a la Investigacion, Desarrollo Tecnologico e Innovacion 2016 and Grupo Banco Santander for providing a fellowship to Veronica Luque-Agudo.
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