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The author(s) declare that financial support was received for the research and/or publication of this article. This research was funded by the Medical Research Council UK (MR/V002465/1). This work was supported by core funding from the Wellcome/EPSRC Centre for Medical Engineering [WT203148/Z/16/Z] and by the National Institute for Health and Care Research (NIHR) Clinical Research Facility at Guy's and St Thomas' NHS Foundation Trust. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care.
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Cordero-Grande, LucilioAuthorVerifying the concordance between motion corrected and conventional MPRAGE for pediatric morphometric analysis
Publicated to:Frontiers In Neuroscience. 19 1534924- - 2025-05-09 19(), DOI: 10.3389/fnins.2025.1534924
Authors: Gal-Er, Barat; Brackenier, Yannick; Bonthrone, Alexandra F; Casella, Chiara; Price, Anthony; Arulkumaran, Sophie; Chew, Andrew T M; Nosarti, Chiara; Cleri, Michela; Di Cio, Pierluigi; Egloff, Alexia; Rutherford, Mary A; O'Muircheartaigh, Jonathan; Tomi-Tricot, Raphael; Malik, Shaihan; Cordero-Grande, Lucilio; Hajnal, Joseph V; Counsell, Serena J
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Abstract
Purpose This study aimed to validate a retrospective motion correction technique, Distributed and Incoherent Sample Orders for Reconstruction Deblurring using Encoding Redundancy (DISORDER), for pediatric brain morphometry.Methods Two T1-weighted MPRAGE 3D datasets were acquired at 3 T in thirty-seven children aged 7-8 years: one with conventional linear phase encoding and one using DISORDER. MPRAGE images were scored as motion-free or motion-corrupt. Cortical morphometry and regional brain volumes were measured with FreeSurfer, subcortical grey matter (GM) with FSL-FIRST, and hippocampi with HippUnfold. Intraclass correlation coefficient (ICC) was used to determine agreement. Mann-Whitney U was used to test the difference between measures obtained using DISORDER and (i) motion-free and (ii) motion-corrupt conventional MPRAGE data.Results ICC measures between conventional MPRAGE and DISORDER data were good/excellent for most subcortical GM (motion-free, 0.75-0.96; motion-corrupt, 0.62-0.98) and regional brain volumes (motion-free 0.47-0.99; motion-corrupt, 0.54-0.99), except for the amygdala and nucleus accumbens (motion-free, 0.38-0.65; motion-corrupt, 0.1-0.42). These values were less consistent for motion-corrupt conventional MPRAGE data for hippocampal volumes (motion-free 0.65-0.99; motion-corrupt, 0.11-0.91) and cortical measures (motion-free 0.76-0.98; motion-corrupt, 0.09-0.74). Mann-Whitney U showed percentage differences in measures obtained with motion-corrupt conventional MPRAGE compared to DISORDER data were significantly greater than in those obtained using motion-free conventional MPRAGE data in 22/58 structures.Conclusion In the absence of motion, morphometric measures obtained using DISORDER are largely consistent with those from conventional MPRAGE data, whereas improved reliability is obtained by DISORDER for motion-degraded scans. This study validates the use of DISORDER for brain morphometric studies in children.
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The work has been published in the journal Frontiers In Neuroscience due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 129/310, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Neurosciences. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría .
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This work has been carried out with international collaboration, specifically with researchers from: United Kingdom.