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This work is supported by the projects RTI2018-095946-B-I00, BIO2017-83472-R from MICIU and by "Severo Ochoa Programme for Centres of Excellence in R&D" from the Agencia Estatal de Investigacion of Spain (grant SEV-20160672 [2017-2021] to the CBGP). In the frame of this latter program R. T. and S. M. were supported with postdoctoral contracts.

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Munoz, AAuthorSantamaria, MeAuthorMangano, SAuthorToribio, RAuthorMartinez, MAuthorBerrocal-Lobo, MAuthorDiaz, IAuthorCastellano, MmCorresponding Author

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December 13, 2021
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Article
Hybrid Gold

The co-chaperone HOP3 participates in jasmonic acid signaling by regulating CORONATINE-INSENSITIVE 1 activity

Publicated to:Plant Physiology. 187 (3): 1679-1689 - 2021-11-01 187(3), DOI: 10.1093/plphys/kiab334

Authors: Munoz, Alfonso; Estrella Santamaria, M; Fernandez-Bautista, Nuria; Mangano, Silvina; Toribio, Rene; Martinez, Manuel; Berrocal-Lobo, Marta; Diaz, Isabel; Mar Castellano, M

Affiliations

Consejo Nacl Invest Cient & Tecn, Fdn Inst Leloir, Av Patricias Argentinas 435,C1405BWE, Buenos Aires, DF, Argentina - Author
Consejo Nacl Invest Cient & Tecn, Inst Invest Bioquim Buenos Aires IIBA, Av Patricias Argentinas 435,C1405BWE, Buenos Aires, DF, Argentina - Author
Escuela Tecn Super Ingn Agron Alimentaria & Biosi, Dept Biotecnol Biol Vegetal, Madrid 28040, Spain - Author
ETSI Montes Forestal & Medio Nat, Dept Sistemas & Recursos Nat, Ciudad Univ S-N, Madrid 28040, Spain - Author
Univ Cordoba, Dept Bot Ecol & Fisiol Vegetal, Campus Rabanales,Edificio Severo Ochoa, Cordoba 14071, Spain - Author
Univ Politecn Madrid UPM, Ctr Biotecnol & Genom Plantas, Inst Nacl Invest & Tecnol Agr & Alimentaria INIA, Campus Montegancedo UPM, Pozuelo De Alarcon 28223, Madrid, Spain - Author
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Abstract

HOPs (HSP70-HSP90 organizing proteins) are a highly conserved family of HSP70 and HSP90 co-chaperones whose role in assisting the folding of various hormonal receptors has been extensively studied in mammals. In plants, HOPs are mainly associated with stress response, but their potential involvement in hormonal networks remains completely unexplored. In this article we describe that a member of the HOP family, HOP3, is involved in the jasmonic acid (JA) pathway and is linked to plant defense responses not only to pathogens, but also to a generalist herbivore. The JA pathway regulates responses to Botrytis cinerea infection and to Tetranychus urticae feeding; our data demonstrate that the Arabidopsis (Arabidopsis thaliana) hop3-1 mutant shows an increased susceptibility to both. The hop3-1 mutant exhibits reduced sensitivity to JA derivatives in root growth assays and downregulation of different JA-responsive genes in response to methyl jasmonate, further revealing the relevance of HOP3 in the JA pathway. Interestingly, yeast two-hybrid assays and in planta co-immunoprecipitation assays found that HOP3 interacts with COI1, suggesting that COI1 is a target of HOP3. Consistent with this observation, COI1 activity is reduced in the hop3-1 mutant. All these data strongly suggest that, specifically among HOPs, HOP3 plays a relevant role in the JA pathway by regulating COI1 activity in response to JA and, consequently, participating in defense signaling to biotic stresses.

Keywords

ArabidopsisArabidopsis proteinArabidopsis proteinsChaperoneCoi1 protein, arabidopsisCyclopentane derivativeCyclopentanesDefense responsesGeneticsHop3 protein, arabidopsisHsp90Jasmonic acidJaz repressorsMetabolismMethyl jasmonateMolecular chaperonesMyc transcription factorsOxylipinOxylipinsPhysiologyPhytohormonePlant defensePlant growth regulatorsProteinsReceptorResistanceSignal transduction

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Plant Physiology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 12/239, thus managing to position itself as a Q1 (Primer Cuartil), in the category Plant Sciences. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.04, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-30, the following number of citations:

  • WoS: 9
  • Scopus: 9
  • Europe PMC: 5

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-30:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 16.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 15 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.35.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://oa.upm.es/87723/

As a result of the publication of the work in the institutional repository, statistical usage data has been obtained that reflects its impact. In terms of dissemination, we can state that, as of

  • Views: 87
  • Downloads: 8

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Argentina.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (MUÑOZ GUTIERREZ, ALFONSO) and Last Author (Castellano Moreno, Mar).

the author responsible for correspondence tasks has been Castellano Moreno, Mar.