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This work is supported by the projects RTI2018-095946-B-I00, BIO2017-83472-R from MICIU and by "Severo Ochoa Programme for Centres of Excellence in R&D" from the Agencia Estatal de Investigacion of Spain (grant SEV-20160672 [2017-2021] to the CBGP). In the frame of this latter program R. T. and S. M. were supported with postdoctoral contracts.
Analysis of institutional authors
Munoz, AAuthorSantamaria, MeAuthorMangano, SAuthorToribio, RAuthorMartinez, MAuthorBerrocal-Lobo, MAuthorDiaz, IAuthorCastellano, MmCorresponding AuthorThe co-chaperone HOP3 participates in jasmonic acid signaling by regulating CORONATINE-INSENSITIVE 1 activity
Publicated to:Plant Physiology. 187 (3): 1679-1689 - 2021-11-01 187(3), DOI: 10.1093/plphys/kiab334
Authors: Munoz, Alfonso; Estrella Santamaria, M; Fernandez-Bautista, Nuria; Mangano, Silvina; Toribio, Rene; Martinez, Manuel; Berrocal-Lobo, Marta; Diaz, Isabel; Mar Castellano, M
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Abstract
HOPs (HSP70-HSP90 organizing proteins) are a highly conserved family of HSP70 and HSP90 co-chaperones whose role in assisting the folding of various hormonal receptors has been extensively studied in mammals. In plants, HOPs are mainly associated with stress response, but their potential involvement in hormonal networks remains completely unexplored. In this article we describe that a member of the HOP family, HOP3, is involved in the jasmonic acid (JA) pathway and is linked to plant defense responses not only to pathogens, but also to a generalist herbivore. The JA pathway regulates responses to Botrytis cinerea infection and to Tetranychus urticae feeding; our data demonstrate that the Arabidopsis (Arabidopsis thaliana) hop3-1 mutant shows an increased susceptibility to both. The hop3-1 mutant exhibits reduced sensitivity to JA derivatives in root growth assays and downregulation of different JA-responsive genes in response to methyl jasmonate, further revealing the relevance of HOP3 in the JA pathway. Interestingly, yeast two-hybrid assays and in planta co-immunoprecipitation assays found that HOP3 interacts with COI1, suggesting that COI1 is a target of HOP3. Consistent with this observation, COI1 activity is reduced in the hop3-1 mutant. All these data strongly suggest that, specifically among HOPs, HOP3 plays a relevant role in the JA pathway by regulating COI1 activity in response to JA and, consequently, participating in defense signaling to biotic stresses.
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Bibliometric impact. Analysis of the contribution and dissemination channel
The work has been published in the journal Plant Physiology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 12/239, thus managing to position itself as a Q1 (Primer Cuartil), in the category Plant Sciences. Notably, the journal is positioned above the 90th percentile.
From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.04, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)
Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-30, the following number of citations:
- WoS: 9
- Scopus: 9
- Europe PMC: 5
Impact and social visibility
Leadership analysis of institutional authors
This work has been carried out with international collaboration, specifically with researchers from: Argentina.
There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (MUÑOZ GUTIERREZ, ALFONSO) and Last Author (Castellano Moreno, Mar).
the author responsible for correspondence tasks has been Castellano Moreno, Mar.