HACEKinfective endocarditis: epidemiology, clinical features outcome: A case-control study.
Publicat a:International Journal Of Infectious Diseases. 76 120-125 - 2018-01-01 76(), DOI: 10.1016/j.ijid.2018.08.013
Autors: Ambrosioni J, Martinez-Garcia C, Llopis J, Garcia-de-la-Maria C, Hernández-Meneses M, Tellez A, Falces C, Almela M, Vidal B, Sandoval E, Fuster D, Quintana E, Tolosana JM, Marco F, Moreno A, Miró JM, Hospital Clinic Infective Endocarditis Investigators
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The study aimed to describe the epidemiology, microbiological and clinical features of a population sample of 17 patients with HACEK-IE and to compare them with matched control patients with IE caused by Viridans group Streptococci (VGS-IE).Description of definite (14; 82.2%) and possible (3; 17.6%) HACEK-IE included in the "Infective Endocarditis Hospital Clínic of Barcelona" (IE-HCB) database between 1979 and 2016. Furthermore, a retrospective case-control analysis was performed, matching each case to three VGS-IE controls registered in the same database during the same period of time.Seventeen out of 1,209 IE cases (1.3%, 95%CI 0.69-1.91) were due to HACEK group. The most frequent isolated HACEK species were Aggregatibacter spp (11; 64.7%). Intracardiac vegetations were present in 70.6% of cases. Left heart failure (LHF) was present in 29.4% of cases. Ten patients (58.8%) required in-hospital surgery and none died during hospitalization. In the case-control analysis, there was a trend toward larger vegetations in the HACEK-IE group (median (IRQ) size=11.5 (10.0-20.0) mm vs 9.0 (7.0-13.0) mm; p=0.068). Clinical manifestations, echocardiographic findings, LHF rate, systemic emboli and other complications were all comparable (p >0.05). In-hospital surgery and mortality were similar for both groups. One-year mortality was lower for HACEK-IE (1/17 vs. to 6/48, p=0.006).HACEK-IE represented 1.3% of all IE cases. Clinical features and outcome were comparable with the VGS-IE control group. Despite the trend toward larger vegetation size, the embolic event rate was not higher and one-year mortality was significantly lower for HACEK-IE.Copyright © 2018. Published by Elsevier Ltd.
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El treball ha estat publicat a la revista International Journal Of Infectious Diseases a causa de la seva progressió i el bon impacte que ha aconseguit en els últims anys, segons l'agència Scopus (SJR), s'ha convertit en una referència en el seu camp. A l'any de publicació del treball, 2018, es trobava a la posició , aconseguint així situar-se com a revista Q1 (Primer Cuartil), en la categoria Medicine (Miscellaneous).
Des d'una perspectiva relativa, i atenent a l'indicador de impacte normalitzat calculat a partir del Field Citation Ratio (FCR) de la font Dimensions, proporciona un valor de: 6.27, el que indica que, comparat amb treballs en la mateixa disciplina i en el mateix any de publicació, el situa com un treball citat per sobre de la mitjana. (font consultada: Dimensions Jun 2025)
Concretament, i atenent a les diferents agències d'indexació, aquest treball ha acumulat, fins a la data 2025-06-01, el següent nombre de cites:
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