Enhancing Microbiome Research through Genome-Scale Metabolic Modeling
Publicated to:Msystems. 6 (6): - 2021-01-01 6(6), DOI: 10.1128/mSystems.00599-21
Authors: Ankrah NYD; Bernstein DB; Biggs M; Carey M; Engevik M; García-Jiménez B; Lakshmanan M; Pacheco AR; Sulheim S; Medlock GL
Affiliations
Abstract
Construction and analysis of genome-scale metabolic models (GEMs) is a well-established systems biology approach that can be used to predict metabolic and growth phenotypes. The ability of GEMs to produce mechanistic insight into microbial ecological processes makes them appealing tools that can open a range of exciting opportunities in microbiome research. Here, we briefly outline these opportunities, present current rate-limiting challenges for the trustworthy application of GEMs to microbiome research, and suggest approaches for moving the field forward. © 2021 Ankrah et al.
Keywords
Quality index
Bibliometric impact. Analysis of the contribution and dissemination channel
The work has been published in the journal Msystems due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 27/137, thus managing to position itself as a Q1 (Primer Cuartil), in the category Microbiology.
From a relative perspective, and based on the normalized impact indicator calculated from World Citations from Scopus Elsevier, it yields a value for the Field-Weighted Citation Impact from the Scopus agency: 2.25, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)
This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:
- Field Citation Ratio (FCR) from Dimensions: 4.96 (source consulted: Dimensions Jun 2025)
Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-03, the following number of citations:
- Scopus: 25
- OpenCitations: 21
Impact and social visibility
Leadership analysis of institutional authors
This work has been carried out with international collaboration, specifically with researchers from: Norway; Singapore; Switzerland; United States of America.