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Grant support

The authors thank Roberto Solano and Andrea Chini (Centro Nacional de Biotecnologia, CNB-CSIC, Madrid) for kindly sharing the myc loss-of-function lines with us. In addition, the authors appreciate the thoughtful feedback and highly valuable comments by all members of the CBGP laboratories 127 and 132. This research was funded by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO), grant number BFU2017-82826-R to S.P.

Analysis of institutional authors

Perez-Alonso, MmCorresponding AuthorSanchez-Parra, BAuthorOrtiz-Garcia, PAuthorSantamaria, MeAuthorDiaz, IAuthorPollmann, SCorresponding Author
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Article

Jasmonic Acid-Dependent MYC Transcription Factors Bind to a Tandem G-Box Motif in the YUCCA8 and YUCCA9 Promoters to Regulate Biotic Stress Responses

Publicated to:International Journal Of Molecular Sciences. 22 (18): 9768- - 2021-09-01 22(18), DOI: 10.3390/ijms22189768

Authors: Perez-Alonso, Marta-Marina; Sanchez-Parra, Beatriz; Ortiz-Garcia, Paloma; Santamaria, Maria Estrella; Diaz, Isabel; Pollmann, Stephan

Affiliations

Karl Franzens Univ Graz, Bereich Pflanzenwissensch, Inst Biol, A-8010 Graz, Austria - Author
Swedish Univ Agr Sci, Umea Plant Sci Ctr UPSC, Dept Forest Genet & Plant Physiol, S-90183 Umea, Sweden - Author
Univ Politecn Madrid UPM, Escuela Tecn Super Ingn Agron Alimentaria & Biosi, Dept Biotecnol Biol Vegetal, Madrid 28040, Spain - Author
Univ Politecn Madrid UPM, Inst Nacl Invest & Tecnol Agr & Alimentac INIA, Ctr Biotecnol & Genom Plantas, Pozuelo De Alarcon 28223, Spain - Author

Abstract

The indole-3-pyruvic acid pathway is the main route for auxin biosynthesis in higher plants. Tryptophan aminotransferases (TAA1/TAR) and members of the YUCCA family of flavin-containing monooxygenases catalyze the conversion of l-tryptophan via indole-3-pyruvic acid to indole-3-acetic acid (IAA). It has been described that jasmonic acid (JA) locally produced in response to mechanical wounding triggers the de novo formation of IAA through the induction of two YUCCA genes, YUC8 and YUC9. Here, we report the direct involvement of a small number of basic helix-loop-helix transcription factors of the MYC family in this process. We show that the JA-mediated regulation of the expression of the YUC8 and YUC9 genes depends on the abundance of MYC2, MYC3, and MYC4. In support of this observation, seedlings of myc knockout mutants displayed a strongly reduced response to JA-mediated IAA formation. Furthermore, transactivation assays provided experimental evidence for the binding of MYC transcription factors to a particular tandem G-box motif abundant in the promoter regions of YUC8 and YUC9, but not in the promoters of the other YUCCA isogenes. Moreover, we demonstrate that plants that constitutively overexpress YUC8 and YUC9 show less damage after spider mite infestation, thereby underlining the role of auxin in plant responses to biotic stress signals.

Keywords
Arabidopsis proteinsArabidopsis thalianaArabidopsis-thalianaAuxin biosynthesisBiotic stressCyclopentanesEscherichia-coliEthylene biosynthesisG-box binding factorsGene expression regulation, plantGene-expressionGrowthGrowth-defense trade-offHeterodimerizationHormone crosstalkIndole-3-acetic acidIndoleacetic acidsJasmonic acidMixed function oxygenasesNucleotide motifsOxylipinsPlant hormone crosstalkPlant-resistancePromoter regions, geneticProtein bindingProto-oncogene proteins c-mycStress, physiologicalTrade-offsTranscriptional regulationWound response

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal International Journal Of Molecular Sciences due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 69/297, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.04. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.07 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 4.96 (source consulted: Dimensions Apr 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-04-30, the following number of citations:

  • WoS: 23
  • Scopus: 25
  • Google Scholar: 18
  • OpenCitations: 16
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-04-30:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 31.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 31 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 6.45.
  • The number of mentions on the social network X (formerly Twitter): 11 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Austria; Sweden.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Perez Alonso, Marta Marina) and Last Author (POLLMANN, STEPHAN).

the authors responsible for correspondence tasks have been Perez Alonso, Marta Marina and POLLMANN, STEPHAN.